Expression and delivery of an endolysin to combat Clostridium perfringens

Clostridium perfringens is a cause for increasing concern due to its responsibility for severe infections both in humans and animals, especially poultry. To find new control strategies to treat C. perfringens infection, we investigated the activity and delivery of a bacteriophage endolysin. We ident...

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Veröffentlicht in:	Applied microbiology and biotechnology 2014-03, Vol.98 (6), p.2495-2505
Hauptverfasser:	Gervasi, Teresa, Horn, Nikki, Wegmann, Udo, Dugo, Giacomo, Narbad, Arjan, Mayer, Melinda J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antimicrobial agents Bacteria Bacteriolysis Bacteriophages Bacteriophages - enzymology Bacteriophages - genetics Biomedical and Life Sciences Biosynthesis Biotechnologically Relevant Enzymes and Proteins Biotechnology chromosomes Cloning, Molecular Clostridium Clostridium perfringens Clostridium perfringens - drug effects Dogs drug effects E coli endolysin Endopeptidases Endopeptidases - genetics Endopeptidases - metabolism Enzymes enzymology Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Food contamination & poisoning gastrointestinal system Gastrointestinal tract Gene Expression Genetic aspects genetics Genomes Gram-positive bacteria humans Infections Lactobacillus Lactobacillus - enzymology Lactobacillus - genetics Lactobacillus johnsonii Lactococcus lactis Lactococcus lactis - genetics Life Sciences metabolism Microbial Genetics and Genomics Microbiology N-acetylmuramoyl-L-alanine amidase nisin operon Pathogens Physiological aspects Poultry Probiotics Proteins secretion signal peptide Signal transduction Viral Proteins Viral Proteins - genetics Viral Proteins - metabolism
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