Dynamics of melanoma tumor therapy with vesicular stomatitis virus: explaining the variability in outcomes using mathematical modeling

Tumor selective, replication competent viruses are being tested for cancer gene therapy. This approach introduces a new therapeutic paradigm due to potential replication of the therapeutic agent and induction of a tumor-specific immune response. However, the experimental outcomes are quite variable,...

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Veröffentlicht in:	Gene therapy 2012-05, Vol.19 (5), p.543-549
Hauptverfasser:	Rommelfanger, D M, Offord, C P, Dev, J, Bajzer, Z, Vile, R G, Dingli, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Antimitotic agents Antineoplastic agents Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cancer therapies Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Diagnosis Drug therapy Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Health aspects Health. Pharmaceutical industry Human Genetics Immune response Immunotherapy Inbreeding Industrial applications and implications. Economical aspects Innate immunity Mathematical models Mathematics Medical sciences Melanoma Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Models, Theoretical Molecular and cellular biology Nanotechnology Oncolytic Virotherapy - methods original-article Physical training Population dynamics Replication Risk factors Skin cancer Stomatitis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumors Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis Indiana virus - immunology Vesicular stomatitis virus Virus Replication Viruses
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