Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus
The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain. The natural...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-7 |
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| creator | Cerqueira Fontinele, Filipe Medeiros Barreto, Humberto Pereira de Oliveira, Aldeídia Arcanjo, Daniel Dias Rufino Cavalcanti dos Santos, Bernadete Helena de Abreu, Aislan Pereira Lira Douglas Melo Coutinho, Henrique Alves Carvalho da Silva, Romezio Oliveira de Sousa, Taciana Freire de Medeiros, Maria das Graças Lopes Citó, Antonia Maria das Graças Dantas Lopes, José Arimateia |
| description | The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain. The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested. However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations. A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested. The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components. These results indicate that L. origanoides H.B.K. can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA. |
| doi_str_mv | 10.1155/2014/305610 |
| format | Article |
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The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested. However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations. A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested. The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components. These results indicate that L. origanoides H.B.K. can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/305610</identifier><identifier>PMID: 24683545</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Acetates - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Bacteria ; Care and treatment ; Chlorpromazine - pharmacology ; Ethanol ; Ethanol - chemistry ; Flavanones - pharmacology ; Gas Chromatography-Mass Spectrometry ; Health aspects ; Herbal medicine ; Hexanes - chemistry ; Lippia ; Lippia - chemistry ; Medicinal plants ; Metabolites ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methylene Chloride - chemistry ; Microbial Sensitivity Tests ; Monoterpenes - pharmacology ; Pharmacology, Experimental ; Phytochemicals ; Phytochemicals - pharmacology ; Plant Extracts - pharmacology ; Staphylococcus aureus ; Staphylococcus aureus infections ; Staphylococcus infections ; Thymol - pharmacology ; Verbena</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Humberto Medeiros Barreto et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Humberto Medeiros Barreto et al. Humberto Medeiros Barreto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Humberto Medeiros Barreto et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-75c89ccc1fc49ef07bf20d1aa6492e4b04b695044c126821d32f692c87ff872b3</citedby><cites>FETCH-LOGICAL-c490t-75c89ccc1fc49ef07bf20d1aa6492e4b04b695044c126821d32f692c87ff872b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934320/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934320/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24683545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Reddy, Aramati B.</contributor><creatorcontrib>Cerqueira Fontinele, Filipe</creatorcontrib><creatorcontrib>Medeiros Barreto, Humberto</creatorcontrib><creatorcontrib>Pereira de Oliveira, Aldeídia</creatorcontrib><creatorcontrib>Arcanjo, Daniel Dias Rufino</creatorcontrib><creatorcontrib>Cavalcanti dos Santos, Bernadete Helena</creatorcontrib><creatorcontrib>de Abreu, Aislan Pereira Lira</creatorcontrib><creatorcontrib>Douglas Melo Coutinho, Henrique</creatorcontrib><creatorcontrib>Alves Carvalho da Silva, Romezio</creatorcontrib><creatorcontrib>Oliveira de Sousa, Taciana</creatorcontrib><creatorcontrib>Freire de Medeiros, Maria das Graças</creatorcontrib><creatorcontrib>Lopes Citó, Antonia Maria das Graças</creatorcontrib><creatorcontrib>Dantas Lopes, José Arimateia</creatorcontrib><title>Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain. The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested. However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations. A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested. The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components. These results indicate that L. origanoides H.B.K. can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA.</description><subject>Acetates - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Care and treatment</subject><subject>Chlorpromazine - pharmacology</subject><subject>Ethanol</subject><subject>Ethanol - chemistry</subject><subject>Flavanones - pharmacology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Hexanes - chemistry</subject><subject>Lippia</subject><subject>Lippia - chemistry</subject><subject>Medicinal plants</subject><subject>Metabolites</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Methylene Chloride - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Monoterpenes - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cerqueira Fontinele, Filipe</au><au>Medeiros Barreto, Humberto</au><au>Pereira de Oliveira, Aldeídia</au><au>Arcanjo, Daniel Dias Rufino</au><au>Cavalcanti dos Santos, Bernadete Helena</au><au>de Abreu, Aislan Pereira Lira</au><au>Douglas Melo Coutinho, Henrique</au><au>Alves Carvalho da Silva, Romezio</au><au>Oliveira de Sousa, Taciana</au><au>Freire de Medeiros, Maria das Graças</au><au>Lopes Citó, Antonia Maria das Graças</au><au>Dantas Lopes, José Arimateia</au><au>Reddy, Aramati B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain. The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested. However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations. A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested. The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components. These results indicate that L. origanoides H.B.K. can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24683545</pmid><doi>10.1155/2014/305610</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2014-01, Vol.2014 (2014), p.1-7 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3934320 |
| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetates - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacteria Care and treatment Chlorpromazine - pharmacology Ethanol Ethanol - chemistry Flavanones - pharmacology Gas Chromatography-Mass Spectrometry Health aspects Herbal medicine Hexanes - chemistry Lippia Lippia - chemistry Medicinal plants Metabolites Methicillin-Resistant Staphylococcus aureus - drug effects Methylene Chloride - chemistry Microbial Sensitivity Tests Monoterpenes - pharmacology Pharmacology, Experimental Phytochemicals Phytochemicals - pharmacology Plant Extracts - pharmacology Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Thymol - pharmacology Verbena |
| title | Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A47%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phytochemical%20Prospection%20and%20Modulation%20of%20Antibiotic%20Activity%20In%20Vitro%20by%20Lippia%20origanoides%20H.B.K.%20in%20Methicillin%20Resistant%20Staphylococcus%20aureus&rft.jtitle=BioMed%20research%20international&rft.au=Cerqueira%20Fontinele,%20Filipe&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/305610&rft_dat=%3Cgale_pubme%3EA427022510%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1505114788&rft_id=info:pmid/24683545&rft_galeid=A427022510&rfr_iscdi=true |