The Interleukin-1 Family: Back to the Future
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). Member...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2013-12, Vol.39 (6), p.1003-1018 |
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| creator | Garlanda, Cecilia Dinarello, Charles A. Mantovani, Alberto |
| description | Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb). A tight regulation via receptor antagonists, decoy receptors, and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. All cells of the innate immune system express and/or are affected by IL-1 family members. Moreover, IL-1 family members play a key role in the differentiation and function of polarized innate and adaptive lymphoid cells. Here we will review the key properties of IL-1 family members, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity. |
| doi_str_mv | 10.1016/j.immuni.2013.11.010 |
| format | Article |
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The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb). A tight regulation via receptor antagonists, decoy receptors, and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. All cells of the innate immune system express and/or are affected by IL-1 family members. Moreover, IL-1 family members play a key role in the differentiation and function of polarized innate and adaptive lymphoid cells. Here we will review the key properties of IL-1 family members, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity.</description><subject>Adaptive Immunity - immunology</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Chemokines</subject><subject>Colon</subject><subject>Gene Expression Regulation</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Innate - immunology</subject><subject>Infections</subject><subject>Inflammatory bowel disease</subject><subject>Interleukin-1 - immunology</subject><subject>Interleukins - immunology</subject><subject>Ischemia</subject><subject>Ligands</subject><subject>Psoriasis</subject><subject>Receptors, Interleukin-1 - immunology</subject><subject>Rodents</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq0KBBT4B1UViQuHJnj8GfeARFG3IK3EBc6W40yKl3xQO1mJf9-slm5bDpw8kp95Z955CfkEtAAK6mJVhK6b-lAwCrwAKCjQD-QIqNG5gJLubWotcq2AH5KPKa0oBSENPSCHTHDOKDNH5Mv9I2a3_Yixxekp9DlkC9eF9uVr9s35p2wcsnEmFtM4RTwh-41rE56-vsfkYfH9_vomX979uL2-WuZeGBhzoauyMryqXS2U49Swhutae23ASXRlI0vFJZOsYqiYV40UqtZSCGiquuHIj8nlVvd5qjqsPfZjdK19jqFz8cUOLtj_f_rwaH8Oa8sN50bCLHD-KhCHXxOm0XYheWxb1-MwJQtCa6kkqA169gZdDVPsZ3sWpKCm5FyYmRJbyschpYjNbhmgdhOHXdltHHYThwWwcxxz2-d_jeya_tz_r1Ocz7kOGG3yAXuPdYjoR1sP4f0JvwFOnpuf</recordid><startdate>20131212</startdate><enddate>20131212</enddate><creator>Garlanda, Cecilia</creator><creator>Dinarello, Charles A.</creator><creator>Mantovani, Alberto</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131212</creationdate><title>The Interleukin-1 Family: Back to the Future</title><author>Garlanda, Cecilia ; 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| subjects | Adaptive Immunity - immunology Animals Arthritis Chemokines Colon Gene Expression Regulation Heart attacks Humans Immune system Immunity, Innate - immunology Infections Inflammatory bowel disease Interleukin-1 - immunology Interleukins - immunology Ischemia Ligands Psoriasis Receptors, Interleukin-1 - immunology Rodents |
| title | The Interleukin-1 Family: Back to the Future |
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