Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach

A major goal of biophysics is to understand the physical mechanisms of biological molecules and systems. Mechanistic models are evaluated based on their ability to explain carefully controlled experiments. By fitting models to data, biophysical parameters that cannot be measured directly can be esti...

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Veröffentlicht in:	The Journal of general physiology 2014-03, Vol.143 (3), p.401-416
Hauptverfasser:	Hines, Keegan E, Middendorf, Thomas R, Aldrich, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bayes Theorem Bayesian analysis Biophysics Calcium Signaling Calmodulin - metabolism Humans Kinetics Methods and Approaches Models, Biological Molecules Nonlinear Dynamics Parameter estimation Protein Binding
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