A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants
Background Hyperglycaemic load has been shown to cause endothelial dysfunction in patients diagnosed with diabetes mellitus or the pre-diabetic state of glucose intolerance. In the non-disease state such as in healthy subjects, the effect of glucose loading is still uncertain with conflicting result...
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| Veröffentlicht in: | Journal of diabetes and metabolic disorders 2014-01, Vol.13 (1), p.9-9, Article 9 |
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| creator | Wong, Siew Yen Hasan, Tayyab Yong, Moi Ling Chong, Chee Fui |
| description | Background
Hyperglycaemic load has been shown to cause endothelial dysfunction in patients diagnosed with diabetes mellitus or the pre-diabetic state of glucose intolerance. In the non-disease state such as in healthy subjects, the effect of glucose loading is still uncertain with conflicting results. The aim of this study was to test the hypothesis that an oral 75 g glucose load will not adversely attenuate the endothelial function of healthy participants, 2 hours postprandial.
Methods
This is a prospective single arm study evaluating the brachial artery flow-mediated vasodilation of 12 healthy participants before and after a 75 g glucose loading. Participants’ age, body mass index, family history of diabetes, fasting blood glucose and 2 hour postprandial glucose levels were recorded. All data were analysed with SPSS 17.0 using Wilcoxon test.
Results
Primary analysis of the participants’ brachial artery flow mediated vasodilation before and 2 hours after 75 g oral glucose loading did not show any statistically significant attenuation (
p
> 0.05) in brachial artery flow-mediated vasodilation, although a trend for reduction in endothelial relaxation was observed. Subgroup analysis of healthy participants with a positive family history of diabetes confirmed a statistically significant attenuation (
p
|
| doi_str_mv | 10.1186/2251-6581-13-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3933197</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A733633743</galeid><sourcerecordid>A733633743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c556t-420a5ab039fdef4a4ebb8c8e91377f05b9e600107b83d07b3268c1a15e12148c3</originalsourceid><addsrcrecordid>eNptks1r3DAQxU1paUKaa49FUCi9OJEsf8iXwhLatBDopT0LWR55FWTJlezAHvOfd8wm201ZGyxb83tPzPhl2XtGrxgT9XVRVCyvK8FyxvP2VXZ-2Hh99H6WXaZ0T_FqGiFY_TY7K0reClrT8-xxQ6YY0gR6tg9AkvWDA6LiSNK89DsSDJm3QMAYJNYv5YnSywwkROXI4BYdEhAXVI9SEvwe933A1VlEzOLRGwso3oJy83ZHJhVnq-2k_JzeZW-Mcgkun9aL7Pe3r79uvud3P29_3Gzucl1V9ZyXBVWV6ihvTQ-mVCV0ndACWsabxtCqa6GmlNGmE7zHJy9qoZliFbCClULzi-zL3ndauhF6DX7GDuQU7ajiTgZl5cuKt1s5hAfJW85Z26DB5yeDGP4skGY52qTBOeUhLEmyihZ4akkrRD_-h96HJXpsT7KaC9E2jJf_qEE5kNabgOfq1VRuGs5rzpuSI3V1gsK7h9Hq4MFY3H8h-HQk2I88BbesPyGddNaYgBTBHIbBqFwDJtcMyTVDknHZouDD8QgP-HOcELjeAwlLfoB41Pdpy78fn9ka</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1638897134</pqid></control><display><type>article</type><title>A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants</title><source>EZB Free E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wong, Siew Yen ; Hasan, Tayyab ; Yong, Moi Ling ; Chong, Chee Fui</creator><creatorcontrib>Wong, Siew Yen ; Hasan, Tayyab ; Yong, Moi Ling ; Chong, Chee Fui</creatorcontrib><description>Background
Hyperglycaemic load has been shown to cause endothelial dysfunction in patients diagnosed with diabetes mellitus or the pre-diabetic state of glucose intolerance. In the non-disease state such as in healthy subjects, the effect of glucose loading is still uncertain with conflicting results. The aim of this study was to test the hypothesis that an oral 75 g glucose load will not adversely attenuate the endothelial function of healthy participants, 2 hours postprandial.
Methods
This is a prospective single arm study evaluating the brachial artery flow-mediated vasodilation of 12 healthy participants before and after a 75 g glucose loading. Participants’ age, body mass index, family history of diabetes, fasting blood glucose and 2 hour postprandial glucose levels were recorded. All data were analysed with SPSS 17.0 using Wilcoxon test.
Results
Primary analysis of the participants’ brachial artery flow mediated vasodilation before and 2 hours after 75 g oral glucose loading did not show any statistically significant attenuation (
p
> 0.05) in brachial artery flow-mediated vasodilation, although a trend for reduction in endothelial relaxation was observed. Subgroup analysis of healthy participants with a positive family history of diabetes confirmed a statistically significant attenuation (
p
< 0.05) in brachial artery flow-mediated vasodilation after acute glucose loading even though the 2 hour postprandial blood glucose level, with a median value of 4.6 ± 2.2 mmol/L was within normal limits. This was not observed in the group without a positive family history of diabetes.
Conclusion
Acute oral glucose loading significantly attenuates endothelial relaxation in healthy subjects with positive family history of diabetes but showed no effect in those without a positive family history of diabetes. The attenuation in endothelial relaxation was observed in the presence of normal glucose metabolism, suggesting a defect in endothelium relaxation even in the non-disease state in the group predisposed to diabetes.</description><identifier>ISSN: 2251-6581</identifier><identifier>EISSN: 2251-6581</identifier><identifier>DOI: 10.1186/2251-6581-13-9</identifier><identifier>PMID: 24398060</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Analysis ; Atherosclerosis ; Blood sugar ; Diabetes ; Endocrinology ; Endothelium ; Glucose metabolism ; Health aspects ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Prediabetic state ; Research Article ; Type 2 diabetes</subject><ispartof>Journal of diabetes and metabolic disorders, 2014-01, Vol.13 (1), p.9-9, Article 9</ispartof><rights>Wong et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Copyright Tehran University of Medical Sciences Publications Jan 2014</rights><rights>Copyright © 2014 Wong et al.; licensee BioMed Central Ltd. 2014 Wong et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-420a5ab039fdef4a4ebb8c8e91377f05b9e600107b83d07b3268c1a15e12148c3</citedby><cites>FETCH-LOGICAL-c556t-420a5ab039fdef4a4ebb8c8e91377f05b9e600107b83d07b3268c1a15e12148c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933197/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933197/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24398060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Siew Yen</creatorcontrib><creatorcontrib>Hasan, Tayyab</creatorcontrib><creatorcontrib>Yong, Moi Ling</creatorcontrib><creatorcontrib>Chong, Chee Fui</creatorcontrib><title>A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants</title><title>Journal of diabetes and metabolic disorders</title><addtitle>J Diabetes Metab Disord</addtitle><addtitle>J Diabetes Metab Disord</addtitle><description>Background
Hyperglycaemic load has been shown to cause endothelial dysfunction in patients diagnosed with diabetes mellitus or the pre-diabetic state of glucose intolerance. In the non-disease state such as in healthy subjects, the effect of glucose loading is still uncertain with conflicting results. The aim of this study was to test the hypothesis that an oral 75 g glucose load will not adversely attenuate the endothelial function of healthy participants, 2 hours postprandial.
Methods
This is a prospective single arm study evaluating the brachial artery flow-mediated vasodilation of 12 healthy participants before and after a 75 g glucose loading. Participants’ age, body mass index, family history of diabetes, fasting blood glucose and 2 hour postprandial glucose levels were recorded. All data were analysed with SPSS 17.0 using Wilcoxon test.
Results
Primary analysis of the participants’ brachial artery flow mediated vasodilation before and 2 hours after 75 g oral glucose loading did not show any statistically significant attenuation (
p
> 0.05) in brachial artery flow-mediated vasodilation, although a trend for reduction in endothelial relaxation was observed. Subgroup analysis of healthy participants with a positive family history of diabetes confirmed a statistically significant attenuation (
p
< 0.05) in brachial artery flow-mediated vasodilation after acute glucose loading even though the 2 hour postprandial blood glucose level, with a median value of 4.6 ± 2.2 mmol/L was within normal limits. This was not observed in the group without a positive family history of diabetes.
Conclusion
Acute oral glucose loading significantly attenuates endothelial relaxation in healthy subjects with positive family history of diabetes but showed no effect in those without a positive family history of diabetes. The attenuation in endothelial relaxation was observed in the presence of normal glucose metabolism, suggesting a defect in endothelium relaxation even in the non-disease state in the group predisposed to diabetes.</description><subject>Analysis</subject><subject>Atherosclerosis</subject><subject>Blood sugar</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Endothelium</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Prediabetic state</subject><subject>Research Article</subject><subject>Type 2 diabetes</subject><issn>2251-6581</issn><issn>2251-6581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNptks1r3DAQxU1paUKaa49FUCi9OJEsf8iXwhLatBDopT0LWR55FWTJlezAHvOfd8wm201ZGyxb83tPzPhl2XtGrxgT9XVRVCyvK8FyxvP2VXZ-2Hh99H6WXaZ0T_FqGiFY_TY7K0reClrT8-xxQ6YY0gR6tg9AkvWDA6LiSNK89DsSDJm3QMAYJNYv5YnSywwkROXI4BYdEhAXVI9SEvwe933A1VlEzOLRGwso3oJy83ZHJhVnq-2k_JzeZW-Mcgkun9aL7Pe3r79uvud3P29_3Gzucl1V9ZyXBVWV6ihvTQ-mVCV0ndACWsabxtCqa6GmlNGmE7zHJy9qoZliFbCClULzi-zL3ndauhF6DX7GDuQU7ajiTgZl5cuKt1s5hAfJW85Z26DB5yeDGP4skGY52qTBOeUhLEmyihZ4akkrRD_-h96HJXpsT7KaC9E2jJf_qEE5kNabgOfq1VRuGs5rzpuSI3V1gsK7h9Hq4MFY3H8h-HQk2I88BbesPyGddNaYgBTBHIbBqFwDJtcMyTVDknHZouDD8QgP-HOcELjeAwlLfoB41Pdpy78fn9ka</recordid><startdate>20140107</startdate><enddate>20140107</enddate><creator>Wong, Siew Yen</creator><creator>Hasan, Tayyab</creator><creator>Yong, Moi Ling</creator><creator>Chong, Chee Fui</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140107</creationdate><title>A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants</title><author>Wong, Siew Yen ; Hasan, Tayyab ; Yong, Moi Ling ; Chong, Chee Fui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-420a5ab039fdef4a4ebb8c8e91377f05b9e600107b83d07b3268c1a15e12148c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Atherosclerosis</topic><topic>Blood sugar</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Endothelium</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Prediabetic state</topic><topic>Research Article</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Siew Yen</creatorcontrib><creatorcontrib>Hasan, Tayyab</creatorcontrib><creatorcontrib>Yong, Moi Ling</creatorcontrib><creatorcontrib>Chong, Chee Fui</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Middle East & Africa Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes and metabolic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Siew Yen</au><au>Hasan, Tayyab</au><au>Yong, Moi Ling</au><au>Chong, Chee Fui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants</atitle><jtitle>Journal of diabetes and metabolic disorders</jtitle><stitle>J Diabetes Metab Disord</stitle><addtitle>J Diabetes Metab Disord</addtitle><date>2014-01-07</date><risdate>2014</risdate><volume>13</volume><issue>1</issue><spage>9</spage><epage>9</epage><pages>9-9</pages><artnum>9</artnum><issn>2251-6581</issn><eissn>2251-6581</eissn><abstract>Background
Hyperglycaemic load has been shown to cause endothelial dysfunction in patients diagnosed with diabetes mellitus or the pre-diabetic state of glucose intolerance. In the non-disease state such as in healthy subjects, the effect of glucose loading is still uncertain with conflicting results. The aim of this study was to test the hypothesis that an oral 75 g glucose load will not adversely attenuate the endothelial function of healthy participants, 2 hours postprandial.
Methods
This is a prospective single arm study evaluating the brachial artery flow-mediated vasodilation of 12 healthy participants before and after a 75 g glucose loading. Participants’ age, body mass index, family history of diabetes, fasting blood glucose and 2 hour postprandial glucose levels were recorded. All data were analysed with SPSS 17.0 using Wilcoxon test.
Results
Primary analysis of the participants’ brachial artery flow mediated vasodilation before and 2 hours after 75 g oral glucose loading did not show any statistically significant attenuation (
p
> 0.05) in brachial artery flow-mediated vasodilation, although a trend for reduction in endothelial relaxation was observed. Subgroup analysis of healthy participants with a positive family history of diabetes confirmed a statistically significant attenuation (
p
< 0.05) in brachial artery flow-mediated vasodilation after acute glucose loading even though the 2 hour postprandial blood glucose level, with a median value of 4.6 ± 2.2 mmol/L was within normal limits. This was not observed in the group without a positive family history of diabetes.
Conclusion
Acute oral glucose loading significantly attenuates endothelial relaxation in healthy subjects with positive family history of diabetes but showed no effect in those without a positive family history of diabetes. The attenuation in endothelial relaxation was observed in the presence of normal glucose metabolism, suggesting a defect in endothelium relaxation even in the non-disease state in the group predisposed to diabetes.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>24398060</pmid><doi>10.1186/2251-6581-13-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2251-6581 |
| ispartof | Journal of diabetes and metabolic disorders, 2014-01, Vol.13 (1), p.9-9, Article 9 |
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| language | eng |
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| source | EZB Free E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Analysis Atherosclerosis Blood sugar Diabetes Endocrinology Endothelium Glucose metabolism Health aspects Medicine Medicine & Public Health Metabolic Diseases Prediabetic state Research Article Type 2 diabetes |
| title | A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants |
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