The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L

A number of marine natural products are potent inhibitors of proteases, an important drug target class in human diseases. Hence, marine cyanobacterial extracts were assessed for inhibitory activity to human cathepsin L. Herein, we have shown that gallinamide A potently and selectively inhibits the h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-01, Vol.77 (1), p.92-99
Hauptverfasser:	Miller, Bailey, Friedman, Aaron J, Choi, Hyukjae, Hogan, James, McCammon, J. Andrew, Hook, Vivian, Gerwick, William H
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence Catalytic Domain cathepsin L Cathepsin L - antagonists & inhibitors Cathepsin L - metabolism cathepsin V Cyanobacteria - chemistry cysteine drugs human diseases Humans hydrogen bonding Inhibitory Concentration 50 Kinetics Marine Biology metabolites molecular dynamics molecular models Molecular Structure Peptides - chemistry Peptides - pharmacology Protease Inhibitors - isolation & purification Protease Inhibitors - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!