STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

Recent genome-wide association studies suggest that genetic factors contribute to primary biliary cirrhosis (PBC) susceptibility. Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully...

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Veröffentlicht in:	Disease markers 2014-01, Vol.2014 (2014), p.1-8
Hauptverfasser:	Umemura, Takeji, Joshita, Satoru, Nakamura, Minoru, Katsuyama, Yoshihiko, Shibata, Soichiro, Kimura, Takefumi, Morita, Susumu, Komatsu, Michiharu, Matsumoto, Akihiro, Yoshizawa, Kaname, Ishibashi, Hiromi, Tanaka, Eiji, Ota, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Antinuclear - blood Antinuclear antibodies Biliary cirrhosis Case-Control Studies Female Gene Frequency Genetic aspects Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Haplotypes Health aspects Humans Interleukin-12 Subunit p35 - genetics Japan Linkage Disequilibrium Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - immunology Male Middle Aged Polymorphism, Single Nucleotide Receptors, Interleukin-12 - genetics Risk factors STAT proteins STAT4 Transcription Factor - genetics
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