The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells

Retinoblastoma (Rb) is the most common intraocular tumor in childhood worldwide. It is a deadly pediatric eye cancer. The main cause of death in Rb patients is intracranial and systemic metastasis. ROCK is the main downstream effector of Ras-homologous (Rho) family of GTPases which are involved in m...

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Veröffentlicht in:	BMC cancer 2014-02, Vol.14 (1), p.89-89, Article 89
Hauptverfasser:	Wang, Jing, Liu, Xiao-Hong, Yang, Zi-Jian, Xie, Bing, Zhong, Yi-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Cell adhesion & migration Cell Adhesion - physiology Cell culture Cell growth Cell Line, Tumor Enzyme Activation - physiology Experiments Humans Kinases Membranes Mortality Motility Neoplasm Invasiveness - pathology Phosphorylation Proteins Retinoblastoma - enzymology Retinoblastoma - pathology rho-Associated Kinases - metabolism Studies Tumors
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