Localization and Functionality of the Inflammasome in Neutrophils

Neutrophils represent the major fraction of circulating immune cells and are rapidly recruited to sites of infection and inflammation. The inflammasome is a multiprotein complex that regulates the generation of IL-1 family proteins. The precise subcellular localization and functionality of the infla...

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Veröffentlicht in:	The Journal of biological chemistry 2014-02, Vol.289 (8), p.5320-5329
Hauptverfasser:	Bakele, Martina, Joos, Melanie, Burdi, Sofia, Allgaier, Nicolas, Pöschel, Simone, Fehrenbacher, Birgit, Schaller, Martin, Marcos, Veronica, Kümmerle-Deschner, Jasmin, Rieber, Nikolaus, Borregaard, Niels, Yazdi, Amir, Hector, Andreas, Hartl, Dominik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carrier Proteins - metabolism Caspases - metabolism Cell Compartmentation Cytokine Gene Expression Profiling Humans Immunity Immunology Inflammasomes - genetics Inflammasomes - metabolism Inflammation Innate Immunity Interleukins - metabolism Intracellular Space - metabolism Neutrophils Neutrophils - metabolism Neutrophils - ultrastructure NLR Family, Pyrin Domain-Containing 3 Protein Pathogen-associated Molecular Pattern (PAMP) Protein Transport RNA, Messenger - genetics RNA, Messenger - metabolism Serine Proteases - metabolism Subcellular Fractions - metabolism Toll-like Receptor (TLR)
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