Cyr61/CTGF/Nov family proteins in gastric carcinogenesis
Gastric cancer(GC)is the second leading cause of cancer-related death.The poor survival rate may reflect the relatively aggressive tumor biology of GC.Recently,the importance of the tumor microenvironment in carcinogenesis has emerged.In the tumor microenvironment,tumor cells and the surrounding str...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-02, Vol.20 (7), p.1694-1700 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Cheng, Tsu-Yao Wu, Ming-Shiang Hua, Kuo-Tai Kuo, Min-Liang Lin, Ming-Tsan |
| description | Gastric cancer(GC)is the second leading cause of cancer-related death.The poor survival rate may reflect the relatively aggressive tumor biology of GC.Recently,the importance of the tumor microenvironment in carcinogenesis has emerged.In the tumor microenvironment,tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis.The Cyr61/CTGF/Nov(CCN)proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes.The evidence suggests that CCN family proteins contribute to GC carcinogenic processes.Here,we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field. |
| doi_str_mv | 10.3748/wjg.v20.i7.1694 |
| format | Article |
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Wu, Ming-Shiang ; Hua, Kuo-Tai ; Kuo, Min-Liang ; Lin, Ming-Tsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-b5012d802162a8e5d25ab70268bacf2a0db00c6348a16ca5c540d32306a6c8173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>angiogenic</topic><topic>Antibodies, Monoclonal - chemistry</topic><topic>Carcinogenesis</topic><topic>CCN Intercellular Signaling Proteins - metabolism</topic><topic>Connective Tissue Growth Factor - metabolism</topic><topic>Cyr61/CTGF/Nov</topic><topic>Cysteine-rich</topic><topic>Cysteine-Rich Protein 61 - metabolism</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Neoplasm Metastasis</topic><topic>Nephroblastoma Overexpressed Protein - metabolism</topic><topic>Protein Sorting Signals</topic><topic>Protein Structure, Tertiary</topic><topic>proteins</topic><topic>RNA Interference</topic><topic>Signal Transduction</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Topic Highlight</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Tsu-Yao</creatorcontrib><creatorcontrib>Wu, Ming-Shiang</creatorcontrib><creatorcontrib>Hua, Kuo-Tai</creatorcontrib><creatorcontrib>Kuo, Min-Liang</creatorcontrib><creatorcontrib>Lin, Ming-Tsan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Tsu-Yao</au><au>Wu, Ming-Shiang</au><au>Hua, Kuo-Tai</au><au>Kuo, Min-Liang</au><au>Lin, Ming-Tsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyr61/CTGF/Nov family proteins in gastric carcinogenesis</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-02-21</date><risdate>2014</risdate><volume>20</volume><issue>7</issue><spage>1694</spage><epage>1700</epage><pages>1694-1700</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Gastric cancer(GC)is the second leading cause of cancer-related death.The poor survival rate may reflect the relatively aggressive tumor biology of GC.Recently,the importance of the tumor microenvironment in carcinogenesis has emerged.In the tumor microenvironment,tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis.The Cyr61/CTGF/Nov(CCN)proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes.The evidence suggests that CCN family proteins contribute to GC carcinogenic processes.Here,we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>24587648</pmid><doi>10.3748/wjg.v20.i7.1694</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | angiogenic Antibodies, Monoclonal - chemistry Carcinogenesis CCN Intercellular Signaling Proteins - metabolism Connective Tissue Growth Factor - metabolism Cyr61/CTGF/Nov Cysteine-rich Cysteine-Rich Protein 61 - metabolism Gene Expression Regulation, Neoplastic Humans Neoplasm Metastasis Nephroblastoma Overexpressed Protein - metabolism Protein Sorting Signals Protein Structure, Tertiary proteins RNA Interference Signal Transduction Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Topic Highlight |
| title | Cyr61/CTGF/Nov family proteins in gastric carcinogenesis |
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