Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin

The statins are now recognized to have pleiotropic properties, including augmentation of endothelial barrier function. To explore the mechanisms involved, we investigated the effect of simvastatin on endothelial cell (EC) tight junctions. Western blotting of human pulmonary artery ECs treated with s...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2014-02, Vol.50 (2), p.328-336
Hauptverfasser:	Chen, Weiguo, Sharma, Rajesh, Rizzo, Alicia N, Siegler, Jessica H, Garcia, Joe G N, Jacobson, Jeffrey R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - metabolism Acute Lung Injury - therapy Animals beta Catenin - metabolism Capillary Permeability - physiology Cell culture Cells, Cultured Claudin-5 - genetics Claudin-5 - metabolism Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Gene Expression Regulation - drug effects Gene Silencing - physiology Humans Kinases Lung - metabolism Mice Mice, Inbred C57BL Molecular weight Original Research Permeability Phosphorylation Proteins Pulmonary arteries Simvastatin - metabolism Simvastatin - pharmacology Statins Tight Junctions - drug effects Tight Junctions - metabolism
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