Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In Vivo Carcinogenesis in Human Prostate Epithelium

Previous studies in rodent models have shown that early-life exposure to bisphenol A (BPA) reprograms the prostate and enhances its susceptibility to hormonal carcinogenesis with aging. To determine whether the human prostate is similarly sensitive to BPA, the current study used human prostate epith...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2014-03, Vol.155 (3), p.805-817
Hauptverfasser:	Prins, Gail S, Hu, Wen-Yang, Shi, Guang-Bin, Hu, Dan-Ping, Majumdar, Shyama, Li, Guannan, Huang, Ke, Nelles, Jason L, Ho, Shuk-Mei, Walker, Cheryl Lyn, Kajdacsy-Balla, Andre, van Breemen, Richard B
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Adenocarcinoma Aging AKT protein Animal models Animals Benzhydryl Compounds - toxicity Bisphenol A Body weight Cancer Carcinogenesis Carcinogenicity Carcinogens Cell culture Cell self-renewal Cells (biology) Cells, Cultured Chromatography, High Pressure Liquid Endocrine-Disrupting Chemicals Epithelium Epithelium - drug effects Epithelium - pathology Estrogens - metabolism Estrogens, Non-Steroidal - toxicity Exposure Flow Cytometry Grafting Health risks Humans In vivo methods and tests Kidney transplantation Male Mesenchyme Mice Mice, Nude Oral administration Phenols - toxicity Progenitor cells Prostate Prostate - cytology Prostate - drug effects Prostate cancer Prostatic Neoplasms - chemically induced Prostatic Neoplasms - pathology Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Sex hormones Signal Transduction Stem Cells - cytology Stem Cells - drug effects Tandem Mass Spectrometry Testosterone Time Factors Young Adult
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