Fetal and Neonatal Iron Deficiency Exacerbates Mild Thyroid Hormone Insufficiency Effects on Male Thyroid Hormone Levels and Brain Thyroid Hormone-Responsive Gene Expression

Fetal/neonatal iron (Fe) and iodine/TH deficiencies lead to similar brain developmental abnormalities and often coexist in developing countries. We recently demonstrated that fetal/neonatal Fe deficiency results in a mild neonatal thyroidal impairment, suggesting that TH insufficiency contributes to...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2014-03, Vol.155 (3), p.1157-1167
Hauptverfasser:	Bastian, Thomas W, Prohaska, Joseph R, Georgieff, Michael K, Anderson, Grant W
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Brain Brain - metabolism Brain injury Cerebral Cortex - metabolism Developing countries Disease Models, Animal Female Fetuses Gene Expression Gene Expression Regulation Hairless Hippocampus Hippocampus - metabolism Iodine Iron Iron - deficiency LDCs Male Maternal Exposure Neonates Neurodevelopmental disorders Nutrient deficiency Parvalbumin Parvalbumins - metabolism Postpartum period Pregnancy Propylthiouracil - chemistry Radioimmunoassay Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sex Factors Thyroid Thyroid gland Thyroid Gland - metabolism Thyroid Hormones - deficiency Thyroid Hormones - metabolism Thyroid-TRH-TSH Thyroxine Triiodothyronine
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