Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors

The design and synthesis of a series of substituted heteroaromatic α4β2α5 positive allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogues, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile (5k...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2014-01, Vol.24 (2), p.674-678
Hauptverfasser: Jin, Zhuang, Khan, Pasha, Shin, Youseung, Wang, Jingyi, Lin, Li, Cameron, Michael D., Lindstrom, Jon M., Kenny, Paul J., Kamenecka, Theodore M.
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Sprache:eng
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