Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1

The incretin hormone Glucagon-like peptide 1 (GLP-1) requires delivery by injection for the treatment of Type 2 diabetes mellitus. Here, we test if the properties of glycosphingolipid trafficking in epithelial cells can be applied to convert GLP-1 into a molecule suitable for mucosal absorption. GLP...

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Veröffentlicht in:	Journal of controlled release 2014-02, Vol.175, p.72-78
Hauptverfasser:	te Welscher, Yvonne M., Chinnapen, Daniel J.-F., Kaoutzani, Lydia, Mrsny, Randall J., Lencer, Wayne I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Ceramides - chemistry Ceramides - metabolism Diabetes Mellitus, Type 2 - drug therapy Drug Carriers - chemistry Drug Carriers - metabolism Drug delivery G(M1) Ganglioside - chemistry G(M1) Ganglioside - metabolism Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - chemistry GM1 HEK293 Cells hGLP-1 Humans Incretins - administration & dosage Incretins - chemistry Male Mice Mice, Inbred C57BL Models, Molecular Molecular Sequence Data Transcytosis
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