Molecular Mechanisms of Influenza Inhibition by Surfactant Protein D Revealed by Large-scale Molecular Dynamics Simulation

Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. SP-D interactions with highly branched viral N-linked glycans on hemagglutinin (HA), an abundant IAV envelope protein and critical virulence factor, promote viral aggregati...

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Veröffentlicht in:	Biochemistry (Easton) 2013-11, Vol.52 (47), p.8527-8538
Hauptverfasser:	Goh, Boon Chong, Rynkiewicz, Michael J., Cafarella, Tanya R., White, Mitchell R., Hartshorn, Kevan L., Allen, Kimberly, Crouch, Erika C., Calin, Oliviana, Seeberger, Peter H., Schulten, Klaus, Seaton, Barbara A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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