Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

Background & Aims Increasing grade of pancreatic intraepithelial neoplasia (PanIN) has been associated with progression to pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that control progression from PanINs to PDAC are not well understood. We investigated the genetic alteration...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2013-11, Vol.145 (5), p.1098-1109.e1
Hauptverfasser:	Murphy, Stephen J, Hart, Steven N, Lima, Joema Felipe, Kipp, Benjamin R, Klebig, Mitchell, Winters, Jennifer L, Szabo, Csilla, Zhang, Lizhi, Eckloff, Bruce W, Petersen, Gloria M, Scherer, Steven E, Gibbs, Richard A, McWilliams, Robert R, Vasmatzis, George, Couch, Fergus J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma in Situ - genetics Carcinoma in Situ - pathology Disease Progression DNA, Neoplasm - genetics Gastroenterology and Hepatology Humans LCM Mutation - genetics Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Pancreas Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Retrospective Studies Tumor Suppressor Protein p53 - genetics Tumorigenesis Whole-Genome Amplification
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