Modulators of the Sphingosine 1-phosphate receptor 1

The Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in autoimmune settings. S1P1-R is a validated drug target for multiple sclerosis (MS) for which FTY720 (Fingolimod), a S1P1,3–5-R pan-agonist, was recently approved as the first orally...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (23), p.6377-6389
Hauptverfasser:	Urbano, Mariangela, Guerrero, Miguel, Rosen, Hugh, Roberts, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases Bradycardia drug therapy drugs FTY720 half life Humans Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Receptors, Lysosphingolipid - chemistry Receptors, Lysosphingolipid - metabolism S1P1-R agonists S1P1-R antagonists sclerosis Signal Transduction sphingosine Structure-Activity Relationship structure-activity relationships
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