Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus
Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-13 |
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| creator | Barro, Nicolas Patrick, Van Damme Brestic, Marian Zerbo, Patrice Sytar, Oksana Yomalan, Kassi Konaté, K. Gagniuc, Paul |
| description | Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes. |
| doi_str_mv | 10.1155/2014/867075 |
| format | Article |
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In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2014/867075</identifier><identifier>PMID: 24616741</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antidiabetics ; Antihypertensives ; Antioxidants ; Carbohydrate metabolism ; Carbohydrates ; Chelation ; Cholesterol ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Drug therapy ; Enzymes ; Flavonoids ; Food ; Free radicals ; Herbal medicine ; Hyperglycemia ; Hypertension ; Insulin resistance ; Iron ; Leaves ; Linoleic acid ; Lipid peroxidation ; Lipids ; Medicinal plants ; Metabolic disorders ; Metabolites ; Nutrition ; Peroxidation ; R&D ; Research & development ; Rodents ; Secondary metabolites ; Therapeutic applications ; Toxicology ; Trichilia ; β-Carotene</subject><ispartof>Evidence-based complementary and alternative medicine, 2014-01, Vol.2014 (2014), p.1-13</ispartof><rights>Copyright © 2014 Kiessoun Konaté et al.</rights><rights>Copyright © 2014 Kiessoun Konaté et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2014 Kiessoun Konaté et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-70be1e2e5124167902a0fb2fd32b3628b08b8e9d42b6b24f6ba43d15efdeac33</citedby><cites>FETCH-LOGICAL-c467t-70be1e2e5124167902a0fb2fd32b3628b08b8e9d42b6b24f6ba43d15efdeac33</cites><orcidid>0000-0002-6597-7838</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926250/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926250/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24616741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Eddouks, Mohamed</contributor><creatorcontrib>Barro, Nicolas</creatorcontrib><creatorcontrib>Patrick, Van Damme</creatorcontrib><creatorcontrib>Brestic, Marian</creatorcontrib><creatorcontrib>Zerbo, Patrice</creatorcontrib><creatorcontrib>Sytar, Oksana</creatorcontrib><creatorcontrib>Yomalan, Kassi</creatorcontrib><creatorcontrib>Konaté, K.</creatorcontrib><creatorcontrib>Gagniuc, Paul</creatorcontrib><title>Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.</description><subject>Animals</subject><subject>Antidiabetics</subject><subject>Antihypertensives</subject><subject>Antioxidants</subject><subject>Carbohydrate metabolism</subject><subject>Carbohydrates</subject><subject>Chelation</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Drug therapy</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Food</subject><subject>Free radicals</subject><subject>Herbal medicine</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Insulin 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barro, Nicolas</au><au>Patrick, Van Damme</au><au>Brestic, Marian</au><au>Zerbo, Patrice</au><au>Sytar, Oksana</au><au>Yomalan, Kassi</au><au>Konaté, K.</au><au>Gagniuc, Paul</au><au>Eddouks, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24616741</pmid><doi>10.1155/2014/867075</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6597-7838</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Animals Antidiabetics Antihypertensives Antioxidants Carbohydrate metabolism Carbohydrates Chelation Cholesterol Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Drug therapy Enzymes Flavonoids Food Free radicals Herbal medicine Hyperglycemia Hypertension Insulin resistance Iron Leaves Linoleic acid Lipid peroxidation Lipids Medicinal plants Metabolic disorders Metabolites Nutrition Peroxidation R&D Research & development Rodents Secondary metabolites Therapeutic applications Toxicology Trichilia β-Carotene |
| title | Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus |
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