Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy

In female mammals, one of the two X chromosomes is transcriptionally silenced to equalize X-linked gene dosage relative to XY males, a process termed X chromosome inactivation. Mechanistically, this is thought to occur via directed recruitment of chromatin modifying factors by the master regulator,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-02, Vol.111 (6), p.2235-2240
Hauptverfasser:	Cerase, Andrea, Smeets, Daniel, Tang, Y. Amy, Gdula, Michal, Kraus, Felix, Spivakov, Mikhail, Moindrot, Benoit, Leleu, Marion, Tattermusch, Anna, Demmerle, Justin, Nesterova, Tatyana B., Green, Catherine, Otte, Arie P., Schermelleh, Lothar, Brockdorff, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biological Sciences Cell Line Cell lines Cells Cellular differentiation Chromatin Chromosomes Gene expression Gene Silencing Genes Mice Microscopy Microscopy, Electron Oligonucleotide Array Sequence Analysis Polycomb-Group Proteins - isolation & purification Proteins RNA RNA - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - isolation & purification Stem cells Transcription, Genetic Transgenes X Chromosome inactivation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!