Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses

•C12–C20 oxidized and reduced forms of XRCC1 were verified in mouse fibroblasts.•Pol β binding affinity to the XRCC1 NTD decreased with the reduced C12A mutant.•Folding properties of full-length C12A and wild-type XRCC1 were indistinguishable.•MMS-induced cellular PAR level was highly elevated in C1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2013-09, Vol.12 (9), p.774-785
Hauptverfasser:	Horton, Julie K., Stefanick, Donna F., Gassman, Natalie R., Williams, Jason G., Gabel, Scott A., Cuneo, Matthew J., Prasad, Rajendra, Kedar, Padmini S., DeRose, Eugene F., Hou, Esther W., London, Robert E., Wilson, Samuel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylamine - analogs & derivatives 1-Naphthylamine - pharmacology Animals Antineoplastic Agents, Alkylating - pharmacology Cell Cycle - drug effects Cells, Cultured DNA Damage DNA Polymerase beta - metabolism DNA polymerase β DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Hydrogen Peroxide - pharmacology Inhibitory Concentration 50 Methyl methanesulfonate Methyl Methanesulfonate - pharmacology Mice Mice, Knockout Models, Molecular Mutation, Missense Naphthalimides - pharmacology Nuclear Magnetic Resonance, Biomolecular Oxidants - pharmacology Oxidation-Reduction PARP inhibitor PARP-1 Poly (ADP-Ribose) Polymerase-1 Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Protein Binding Protein Structure, Tertiary Quinolones - pharmacology Transition Temperature X-ray Repair Cross Complementing Protein 1 XRCC1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!