A Genome-wide Association Analysis of a Broad Psychosis Phenotype Identifies Three Loci for Further Investigation

Background Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories. Methods 1239 cases with schizophrenia, schizoaffective disorde...

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Veröffentlicht in:	Biological psychiatry (1969) 2014-03, Vol.75 (5), p.386-397
Hauptverfasser:	BRAMON, Elvira, PIRINEN, Matti, LANGFORD, Cordelia, DELOUKAS, Panos, HUNT, Sarah, GRAY, Emma, DRONOV, Serge, POTTER, Simon C, TASHAKKORI-GHANBARIA, Avazeh, EDKINS, Sarah, BUMPSTEAD, Suzannah J, ARRANZ, Maria J, STRANGE, Amy, BAKKER, Steven, BENDER, Stephan, BRUGGEMAN, Richard, CAHN, Wiepke, CHANDLER, David, COLLIER, David A, CRESPO-FACORRO, Benedicto, DAZZAN, Paola, DE HAAN, Lieuwe, DI FORTI, Marta, KUANG LIN, DRAGOVIC, Milan, GIEGLING, Ina, HALL, Jeremy, LYEGBE, Conrad, JOBLENSKY, Assen, KAHN, René S, KALAYDJIEVA, Luba, KRAVARITI, Eugenia, LAWRIE, Stephen, LINSZEN, Don H, FREEMAN, Colin, MATA, Ignacio, MCDONALD, Colm, MCINTOSH, Andrew, MYIN-GERMEYS, Inez, OPHOFF, Roel A, PARIANTE, Carmine M, PAUNIO, Tiina, PICCHIONI, Marco, RIPKE, Stephan, RUJESCU, Dan, BELLENGUEZ, Celine, SAUER, Heinrich, SHAIKH, Madiha, SUSSMANN, Jessika, SUVISAARI, Jaana, TOSATO, Sarah, TOULOPOULOU, Timothea, VAN OS, Jim, WALSHE, Muriel, WEISBROD, Matthias, WHALLEY, Heather, ZHAN SU, BAND, Gavin, PEARSON, Richard, VUKCEVIC, Damjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Archival Report Biological and medical sciences Bipolar disorder Bipolar disorders Female Genetic Association Studies genome-wide association Genotype Humans Male Medical sciences meta-analysis Miscellaneous Mood disorders Phenotype polygenic score analysis Polymorphism, Single Nucleotide - genetics Principal Component Analysis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses psychosis Psychotic Disorders - genetics Schizophrenia Schizophrenia - genetics
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