BAP1 is phosphorylated at serine 592 in S-phase following DNA damage

•BAP1 is phosphorylated at Ser592 (pS592) following DNA damage or replication stress.•Phosphorylation of BAP1 is rapid and occurs in S-phase to a small fraction of BAP1.•In contrast to the majority of BAP1, pS592-BAP1 is not associated with chromatin. The human BAP1 deubiquitinating enzyme is a chro...

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Veröffentlicht in:	FEBS letters 2013-12, Vol.587 (24), p.3906-3911
Hauptverfasser:	Eletr, Ziad M., Yin, Luming, Wilkinson, Keith D.
Format:	Artikel
Sprache:	eng
Schlagworte:	BAP1 cell proliferation chromatin Deubiquitinating enzyme DNA DNA damage DNA Damage - physiology Gene Expression Regulation genes HeLa Cells Humans Phosphorylation Phosphorylation - radiation effects Promoter Regions, Genetic Protein Binding Protein Interaction Domains and Motifs - genetics Protein-Serine-Threonine Kinases - metabolism S Phase - genetics S Phase - radiation effects serine Serine - metabolism transcription factors Tumor Cells, Cultured Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin Ubiquitin Thiolesterase - chemistry Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ultraviolet Rays
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