Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin

Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin

ObjectiveThe effect of metformin on weight reduction in polycystic ovary syndrome (PCOS) is often unsatisfactory. In this study, we investigated the potential add-on effect of treatment with the glucagon-like peptide-1 receptor agonist liraglutide on weight loss in obese nondiabetic women with PCOS...

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Veröffentlicht in:European journal of endocrinology 2014-03, Vol.170 (3), p.451-459
Hauptverfasser: Jensterle Sever, Mojca, Kocjan, Tomaz, Pfeifer, Marija, Kravos, Nika Aleksandra, Janez, Andrej
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Body Weight - drug effects
Clinical Study
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Glucagon-Like Peptide 1 - administration & dosage
Glucagon-Like Peptide 1 - analogs & derivatives
Glucagon-Like Peptide-1 Receptor
Humans
Liraglutide
Medical sciences
Metabolic diseases
Metformin - administration & dosage
Obesity
Obesity - drug therapy
Receptors, Glucagon - agonists
Vertebrates: endocrinology
Waist Circumference
Weight Loss - drug effects
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Zusammenfassung:ObjectiveThe effect of metformin on weight reduction in polycystic ovary syndrome (PCOS) is often unsatisfactory. In this study, we investigated the potential add-on effect of treatment with the glucagon-like peptide-1 receptor agonist liraglutide on weight loss in obese nondiabetic women with PCOS who had lost
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-13-0797