Physiology in medicine: obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy
We review evidence in support of significant contributions to the pathogenesis of obstructive sleep apnea (OSA) from pathophysiological factors beyond the well-accepted importance of airway anatomy. Emphasis is placed on contributions from neurochemical control of central respiratory motor output th...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2014-01, Vol.116 (1), p.3-12 |
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| container_title | Journal of applied physiology (1985) |
| container_volume | 116 |
| creator | Dempsey, Jerome A Xie, Ailiang Patz, David S Wang, David |
| description | We review evidence in support of significant contributions to the pathogenesis of obstructive sleep apnea (OSA) from pathophysiological factors beyond the well-accepted importance of airway anatomy. Emphasis is placed on contributions from neurochemical control of central respiratory motor output through its effects on output stability, upper airway dilator muscle activation, and arousability. In turn, we consider the evidence demonstrating effective treatment of OSA via approaches that address each of these pathophysiologic risk factors. Finally, a case is made for combining treatments aimed at both anatomical and ventilatory control system deficiencies and for individualizing treatment to address a patient's own specific risk factors. |
| doi_str_mv | 10.1152/japplphysiol.01054.2013 |
| format | Article |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2014-01, Vol.116 (1), p.3-12 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Airway management Animals Humans Pathogenesis Physiology Physiology in Medicine Respiratory System - pathology Respiratory System - physiopathology Sleep apnea Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - physiopathology |
| title | Physiology in medicine: obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy |
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