miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury

MicroRNAs (miRNAs) have a role in the cellular defense mechanism. Nuclear factor erythroid-2-related factor 2 (Nrf2) increases antioxidant enzyme capacity. However, miRNA transcriptionally controlled by Nrf2 had been uncharacterized. Here we report that miR-125b is transactivated by Nrf2 and inhibit...

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Veröffentlicht in:	Cell death & disease 2013-10, Vol.4 (10), p.e899-e899
Hauptverfasser:	Joo, M S, Lee, C G, Koo, J H, Kim, S G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/80 692/699/1585 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Chromatin Immunoprecipitation Cisplatin - adverse effects Computational Biology Hep G2 Cells Humans Immunoblotting Immunology Kidney - drug effects Kidney - metabolism Life Sciences Male Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Original original-article Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Reverse Transcriptase Polymerase Chain Reaction
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