Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice

Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice

We present wavefront sensorless adaptive optics (WSAO) Fourier domain optical coherence tomography (FD-OCT) for in vivo small animal retinal imaging. WSAO is attractive especially for mouse retinal imaging because it simplifies optical design and eliminates the need for wavefront sensing, which is d...

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Veröffentlicht in:Biomedical optics express 2014-02, Vol.5 (2), p.547-559
Hauptverfasser: Jian, Yifan, Xu, Jing, Gradowski, Martin A, Bonora, Stefano, Zawadzki, Robert J, Sarunic, Marinko V
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Active and Adaptive Optics
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container_issue 2
container_start_page 547
container_title Biomedical optics express
container_volume 5
creator Jian, Yifan
Xu, Jing
Gradowski, Martin A
Bonora, Stefano
Zawadzki, Robert J
Sarunic, Marinko V
description We present wavefront sensorless adaptive optics (WSAO) Fourier domain optical coherence tomography (FD-OCT) for in vivo small animal retinal imaging. WSAO is attractive especially for mouse retinal imaging because it simplifies optical design and eliminates the need for wavefront sensing, which is difficult in the small animal eye. GPU accelerated processing of the OCT data permitted real-time extraction of image quality metrics (intensity) for arbitrarily selected retinal layers to be optimized. Modal control of a commercially available segmented deformable mirror (IrisAO Inc.) provided rapid convergence using a sequential search algorithm. Image quality improvements with WSAO OCT are presented for both pigmented and albino mouse retinal data, acquired in vivo.
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subjects Active and Adaptive Optics
title Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice
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