Sustained release of naproxen in a new kind delivery system of carbon nanotubes hydrogel

In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform in...

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Veröffentlicht in:	Iranian journal of pharmaceutical research : IJPR 2013, Vol.12 (4), p.581-586
Hauptverfasser:	Peng, Xiahui, Zhuang, Qiang, Peng, Dongming, Dong, Qiuli, Tan, Lini, Jiao, Feipeng, Liu, Linqi, Liu, Jingyu, Zhao, Chenxi, Wang, Xiaomei
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container_title	Iranian journal of pharmaceutical research : IJPR
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creator	Peng, Xiahui Zhuang, Qiang Peng, Dongming Dong, Qiuli Tan, Lini Jiao, Feipeng Liu, Linqi Liu, Jingyu Zhao, Chenxi Wang, Xiaomei
description	In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
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title	Sustained release of naproxen in a new kind delivery system of carbon nanotubes hydrogel
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