Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure

Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response through the formation of a signaling unit (SU) composed of one double-stranded RNA (dsRNA) and two TLR3 molecules. We report the crystal structure of human TLR3 ectodomain (TLR3ecd) in a quaternary complex with thre...

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Veröffentlicht in:	Journal of molecular biology 2012-08, Vol.421 (1), p.112-124
Hauptverfasser:	Luo, Jinquan, Obmolova, Galina, Malia, Thomas J., Wu, Sheng-Jiun, Duffy, Karen E., Marion, James D., Bell, Jessica K., Ge, Peng, Zhou, Z. Hong, Teplyakov, Alexey, Zhao, Yonghong, Lamb, Roberta J., Jordan, Jarrat L., San Mateo, Lani R., Sweet, Raymond W., Gilliland, Gary L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Affinity Binding Sites Cell Line chemistry crystal structure double-stranded RNA epitopes genetics Humans Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - metabolism immunology innate immunity lateral TLR3 clustering metabolism Models, Molecular Mutation neutralization Protein Structure, Tertiary quaternary complex RNA, Double-Stranded RNA, Double-Stranded - metabolism Signal Transduction TLR3 Toll-Like Receptor 3 Toll-Like Receptor 3 - chemistry Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism
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