Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity

Biochemical experiments in mammalian cells have linked Src family kinase activity to the insulin signaling pathway. To explore the physiological link between Src and a central insulin pathway effector, we investigated the effect of different Src signaling levels on the Drosophila transcription facto...

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Veröffentlicht in:	Scientific reports 2014-02, Vol.4 (1), p.4048-4048, Article 4048
Hauptverfasser:	Bülow, Margret H., Bülow, Torsten R., Hoch, Michael, Pankratz, Michael J., Jünger, Martin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/1 14/63 38 38/77 631/208/2490 631/208/68 631/67/70 631/80/83 64 64/24 Animals Body size Cell Nucleus - metabolism Drosophila - growth & development Drosophila - metabolism Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Drosophila Proteins - metabolism Forkhead Box Protein O3 Forkhead protein Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene expression Gene regulation Humanities and Social Sciences Indoles - pharmacology Insulin Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Larva - growth & development Larva - metabolism Larvae Localization Mammalian cells Mammals Mice multidisciplinary Mutation NIH 3T3 Cells Nuclei Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Phenotype Protein-tyrosine kinase Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - metabolism Receptor, Insulin - metabolism Science Signal transduction Signal Transduction - drug effects Src protein src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics src-Family Kinases - metabolism Sulfonamides - pharmacology Transcription factors Transcription, Genetic
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