PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia
Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical...
Gespeichert in:
| Veröffentlicht in: | Oncology letters 2014-03, Vol.7 (3), p.750-754 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 754 |
|---|---|
| container_issue | 3 |
| container_start_page | 750 |
| container_title | Oncology letters |
| container_volume | 7 |
| creator | NAKABAYASHI, MOTOKI OSAKI, MITSUHIKO KODANI, ISAMU OKADA, FUTOSHI RYOKE, KAZUO OSHIMURA, MITSUO ITO, HISAO KUGOH, HIROYUKI |
| description | Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical genes during the multi-stage transformation of oral epithelial dysplasia to OSCC. PITX1 and Ki-67 expression were assessed by immunohistochemistry in 26 individuals with normal oral mucosa, 106 patients with oral epithelial dysplasia and 97 OSCC patients. The labeling indices (LIs) of PITX1 and Ki-67 were calculated and their correlation with the incidence of malignancy was evaluated. The PITX1 LI of the dysplasia specimens was significantly lower than that of the normal oral mucosa samples, but significantly higher than that of the OSCC samples. The oral epithelial dysplasia patients that exhibited low PITX1 expression showed a significantly higher incidence of malignant transformation than those exhibiting high PITX1 expression, regardless of the histological grades of their oral epithelial dysplasias. On the other hand, no correlation was observed between the Ki-67 LI and the incidence of malignancy. These results suggested that PITX1 suppression is associated with malignant transformation in the oral epithelium and that PITX1 expression may serve as a novel biomarker for predicting prognosis in oral epithelial dysplasia. |
| doi_str_mv | 10.3892/ol.2013.1775 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3919858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A426827930</galeid><sourcerecordid>A426827930</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-49776bd86c3052d409da3e72ad34f7d78482e9a054593be0d798d106cac255693</originalsourceid><addsrcrecordid>eNptks9rFDEUxwdRbKm9eZaAIB6cNT8nyUUoRWuhoIcK3kImyeymZpMxman0vzdD292umEDySD7v-37wmuY1gisiJP6YwgpDRFaIc_asOUZc4hZBgZ_vbE6PmtNSbmBdrENCdC-bI0wZ5lCQ40Z_v7z-iYAvQIPsgtd9cKD3aavzL5fBkDIYs7PeTD6uq5nWMZVK-whGPXkXpwL--GkDUtYBuLGai0oA9q6MQRevXzUvBh2KO324T5ofXz5fn39tr75dXJ6fXbWGUTS1VHLe9VZ0hkCGLYXSauI41pbQgVsuqMBOasgok6R30HIpLIKd0QYz1kly0ny61x3nfuusqanVlNSYfa3lTiXt1eFP9Bu1TreKSCQFE1Xg_YNATr9nVya19cW4EHR0aS4KCdwxwRGlFX37D3qT5hxreQpJgjuMmEB7aq2DUz4OqcY1i6g6o7gTmEsCK7X6D1W3dVtvUnSDr-8HDu-eOGycDtOmpDBPPsVyCH64B01OpWQ37JqBoFrGR6WglvFRy_hU_M3TBu7gx2HZBy6jjtbbVPbdDS3kLST1ZJD8BR4hylo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932621581</pqid></control><display><type>article</type><title>PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>NAKABAYASHI, MOTOKI ; OSAKI, MITSUHIKO ; KODANI, ISAMU ; OKADA, FUTOSHI ; RYOKE, KAZUO ; OSHIMURA, MITSUO ; ITO, HISAO ; KUGOH, HIROYUKI</creator><creatorcontrib>NAKABAYASHI, MOTOKI ; OSAKI, MITSUHIKO ; KODANI, ISAMU ; OKADA, FUTOSHI ; RYOKE, KAZUO ; OSHIMURA, MITSUO ; ITO, HISAO ; KUGOH, HIROYUKI</creatorcontrib><description>Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical genes during the multi-stage transformation of oral epithelial dysplasia to OSCC. PITX1 and Ki-67 expression were assessed by immunohistochemistry in 26 individuals with normal oral mucosa, 106 patients with oral epithelial dysplasia and 97 OSCC patients. The labeling indices (LIs) of PITX1 and Ki-67 were calculated and their correlation with the incidence of malignancy was evaluated. The PITX1 LI of the dysplasia specimens was significantly lower than that of the normal oral mucosa samples, but significantly higher than that of the OSCC samples. The oral epithelial dysplasia patients that exhibited low PITX1 expression showed a significantly higher incidence of malignant transformation than those exhibiting high PITX1 expression, regardless of the histological grades of their oral epithelial dysplasias. On the other hand, no correlation was observed between the Ki-67 LI and the incidence of malignancy. These results suggested that PITX1 suppression is associated with malignant transformation in the oral epithelium and that PITX1 expression may serve as a novel biomarker for predicting prognosis in oral epithelial dysplasia.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2013.1775</identifier><identifier>PMID: 24527083</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Antigens ; biomarker ; Cell cycle ; Development and progression ; Diagnosis ; Dysplasia ; Gene expression ; Genetic markers ; Identification and classification ; immunohistochemistry ; Kinases ; Medical prognosis ; Mouth diseases ; Oncology ; Oral cancer ; oral epithelial dysplasia ; PITX1 ; Proteins ; Squamous cell carcinoma ; Studies ; University faculty</subject><ispartof>Oncology letters, 2014-03, Vol.7 (3), p.750-754</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><rights>Copyright © 2014, Spandidos Publications 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-49776bd86c3052d409da3e72ad34f7d78482e9a054593be0d798d106cac255693</citedby><cites>FETCH-LOGICAL-c541t-49776bd86c3052d409da3e72ad34f7d78482e9a054593be0d798d106cac255693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919858/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919858/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,5556,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24527083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKABAYASHI, MOTOKI</creatorcontrib><creatorcontrib>OSAKI, MITSUHIKO</creatorcontrib><creatorcontrib>KODANI, ISAMU</creatorcontrib><creatorcontrib>OKADA, FUTOSHI</creatorcontrib><creatorcontrib>RYOKE, KAZUO</creatorcontrib><creatorcontrib>OSHIMURA, MITSUO</creatorcontrib><creatorcontrib>ITO, HISAO</creatorcontrib><creatorcontrib>KUGOH, HIROYUKI</creatorcontrib><title>PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical genes during the multi-stage transformation of oral epithelial dysplasia to OSCC. PITX1 and Ki-67 expression were assessed by immunohistochemistry in 26 individuals with normal oral mucosa, 106 patients with oral epithelial dysplasia and 97 OSCC patients. The labeling indices (LIs) of PITX1 and Ki-67 were calculated and their correlation with the incidence of malignancy was evaluated. The PITX1 LI of the dysplasia specimens was significantly lower than that of the normal oral mucosa samples, but significantly higher than that of the OSCC samples. The oral epithelial dysplasia patients that exhibited low PITX1 expression showed a significantly higher incidence of malignant transformation than those exhibiting high PITX1 expression, regardless of the histological grades of their oral epithelial dysplasias. On the other hand, no correlation was observed between the Ki-67 LI and the incidence of malignancy. These results suggested that PITX1 suppression is associated with malignant transformation in the oral epithelium and that PITX1 expression may serve as a novel biomarker for predicting prognosis in oral epithelial dysplasia.</description><subject>Antigens</subject><subject>biomarker</subject><subject>Cell cycle</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dysplasia</subject><subject>Gene expression</subject><subject>Genetic markers</subject><subject>Identification and classification</subject><subject>immunohistochemistry</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Mouth diseases</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>oral epithelial dysplasia</subject><subject>PITX1</subject><subject>Proteins</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>University faculty</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptks9rFDEUxwdRbKm9eZaAIB6cNT8nyUUoRWuhoIcK3kImyeymZpMxman0vzdD292umEDySD7v-37wmuY1gisiJP6YwgpDRFaIc_asOUZc4hZBgZ_vbE6PmtNSbmBdrENCdC-bI0wZ5lCQ40Z_v7z-iYAvQIPsgtd9cKD3aavzL5fBkDIYs7PeTD6uq5nWMZVK-whGPXkXpwL--GkDUtYBuLGai0oA9q6MQRevXzUvBh2KO324T5ofXz5fn39tr75dXJ6fXbWGUTS1VHLe9VZ0hkCGLYXSauI41pbQgVsuqMBOasgok6R30HIpLIKd0QYz1kly0ny61x3nfuusqanVlNSYfa3lTiXt1eFP9Bu1TreKSCQFE1Xg_YNATr9nVya19cW4EHR0aS4KCdwxwRGlFX37D3qT5hxreQpJgjuMmEB7aq2DUz4OqcY1i6g6o7gTmEsCK7X6D1W3dVtvUnSDr-8HDu-eOGycDtOmpDBPPsVyCH64B01OpWQ37JqBoFrGR6WglvFRy_hU_M3TBu7gx2HZBy6jjtbbVPbdDS3kLST1ZJD8BR4hylo</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>NAKABAYASHI, MOTOKI</creator><creator>OSAKI, MITSUHIKO</creator><creator>KODANI, ISAMU</creator><creator>OKADA, FUTOSHI</creator><creator>RYOKE, KAZUO</creator><creator>OSHIMURA, MITSUO</creator><creator>ITO, HISAO</creator><creator>KUGOH, HIROYUKI</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia</title><author>NAKABAYASHI, MOTOKI ; OSAKI, MITSUHIKO ; KODANI, ISAMU ; OKADA, FUTOSHI ; RYOKE, KAZUO ; OSHIMURA, MITSUO ; ITO, HISAO ; KUGOH, HIROYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-49776bd86c3052d409da3e72ad34f7d78482e9a054593be0d798d106cac255693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antigens</topic><topic>biomarker</topic><topic>Cell cycle</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Dysplasia</topic><topic>Gene expression</topic><topic>Genetic markers</topic><topic>Identification and classification</topic><topic>immunohistochemistry</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Mouth diseases</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>oral epithelial dysplasia</topic><topic>PITX1</topic><topic>Proteins</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>University faculty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKABAYASHI, MOTOKI</creatorcontrib><creatorcontrib>OSAKI, MITSUHIKO</creatorcontrib><creatorcontrib>KODANI, ISAMU</creatorcontrib><creatorcontrib>OKADA, FUTOSHI</creatorcontrib><creatorcontrib>RYOKE, KAZUO</creatorcontrib><creatorcontrib>OSHIMURA, MITSUO</creatorcontrib><creatorcontrib>ITO, HISAO</creatorcontrib><creatorcontrib>KUGOH, HIROYUKI</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKABAYASHI, MOTOKI</au><au>OSAKI, MITSUHIKO</au><au>KODANI, ISAMU</au><au>OKADA, FUTOSHI</au><au>RYOKE, KAZUO</au><au>OSHIMURA, MITSUO</au><au>ITO, HISAO</au><au>KUGOH, HIROYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>7</volume><issue>3</issue><spage>750</spage><epage>754</epage><pages>750-754</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical genes during the multi-stage transformation of oral epithelial dysplasia to OSCC. PITX1 and Ki-67 expression were assessed by immunohistochemistry in 26 individuals with normal oral mucosa, 106 patients with oral epithelial dysplasia and 97 OSCC patients. The labeling indices (LIs) of PITX1 and Ki-67 were calculated and their correlation with the incidence of malignancy was evaluated. The PITX1 LI of the dysplasia specimens was significantly lower than that of the normal oral mucosa samples, but significantly higher than that of the OSCC samples. The oral epithelial dysplasia patients that exhibited low PITX1 expression showed a significantly higher incidence of malignant transformation than those exhibiting high PITX1 expression, regardless of the histological grades of their oral epithelial dysplasias. On the other hand, no correlation was observed between the Ki-67 LI and the incidence of malignancy. These results suggested that PITX1 suppression is associated with malignant transformation in the oral epithelium and that PITX1 expression may serve as a novel biomarker for predicting prognosis in oral epithelial dysplasia.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24527083</pmid><doi>10.3892/ol.2013.1775</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1792-1074 |
| ispartof | Oncology letters, 2014-03, Vol.7 (3), p.750-754 |
| issn | 1792-1074 1792-1082 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3919858 |
| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antigens biomarker Cell cycle Development and progression Diagnosis Dysplasia Gene expression Genetic markers Identification and classification immunohistochemistry Kinases Medical prognosis Mouth diseases Oncology Oral cancer oral epithelial dysplasia PITX1 Proteins Squamous cell carcinoma Studies University faculty |
| title | PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T06%3A16%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PITX1%20is%20a%20reliable%20biomarker%20for%20predicting%20prognosis%20in%20patients%20with%20oral%20epithelial%20dysplasia&rft.jtitle=Oncology%20letters&rft.au=NAKABAYASHI,%20MOTOKI&rft.date=2014-03-01&rft.volume=7&rft.issue=3&rft.spage=750&rft.epage=754&rft.pages=750-754&rft.issn=1792-1074&rft.eissn=1792-1082&rft_id=info:doi/10.3892/ol.2013.1775&rft_dat=%3Cgale_pubme%3EA426827930%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932621581&rft_id=info:pmid/24527083&rft_galeid=A426827930&rfr_iscdi=true |