Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage

By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilibrium DNA topology is enigmatic, and the b...

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Veröffentlicht in:	Nucleic acids research 2014-02, Vol.42 (3), p.1821-1830
Hauptverfasser:	Martínez-García, Belén, Fernández, Xavier, Díaz-Ingelmo, Ofelia, Rodríguez-Campos, Antonio, Manichanh, Chaysavanh, Roca, Joaquim
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - metabolism DNA Topoisomerases, Type II - metabolism DNA, Superhelical - metabolism Nucleic Acid Conformation Nucleic Acid Enzymes
Online-Zugang:	Volltext
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