Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

Clinical topoisomerase I (Top1) and II (Top2) inhibitors trap topoisomerases on DNA, thereby inducing protein-linked DNA breaks. Cancer cells resist the drugs by removing topoisomerase-DNA complexes, and repairing the drug-induced DNA double-strand breaks (DSB) by homologous recombination and nonhom...

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Veröffentlicht in:	Molecular cancer therapeutics 2014-01, Vol.13 (1), p.214-220
Hauptverfasser:	Maede, Yuko, Shimizu, Hiroyasu, Fukushima, Toru, Kogame, Toshiaki, Nakamura, Terukazu, Miki, Tsuneharu, Takeda, Shunichi, Pommier, Yves, Murai, Junko
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - drug effects Benzodioxoles - administration & dosage Camptothecin - administration & dosage Cell Line DNA Breaks, Double-Stranded - drug effects DNA Damage - drug effects DNA End-Joining Repair - drug effects DNA Repair - drug effects DNA Repair - genetics DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type II - genetics Homologous Recombination - drug effects Humans Isoquinolines - administration & dosage Signal Transduction - genetics Topoisomerase I Inhibitors - administration & dosage Topoisomerase II Inhibitors - administration & dosage
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