A compensatory effect upon splicing results in normal function of the CYP2A614 allele

A synonymous variant in the first exon of CYP2A6, rs1137115 (51G>A), defines the common reference allele CYP2A6*1A, and is associated with lower mRNA expression and slower in-vivo nicotine metabolism. Another common allele, CYP2A6*14, differs from CYP2A6*1A by a single variant, rs28399435 (86G>...

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Veröffentlicht in:	Pharmacogenetics and genomics 2013-03, Vol.23 (3), p.107-116
Hauptverfasser:	Bloom, A Joseph, Harari, Oscar, Martinez, Maribel, Zhang, Xiaochun, McDonald, Sandra A, Murphy, Sharon E, Goate, Alison
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Aryl Hydrocarbon Hydroxylases - genetics Base Sequence Cytochrome P-450 CYP2A6 DNA Primers Exons Humans Liver - enzymology Real-Time Polymerase Chain Reaction RNA Splicing
Online-Zugang:	Volltext
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