Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses

N-linked glycosylation is a central regulatory factor that influences the immune system in varied and profound ways, including leukocyte homing, T cell receptor signaling and others. Moreover, N-glycan branching has been demonstrated to change as a function of infection and inflammation. Our previou...

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Veröffentlicht in:	Glycobiology (Oxford) 2014-03, Vol.24 (3), p.262-271
Hauptverfasser:	Ryan, Sean O, Leal, Jr, Sixto M, Abbott, Derek W, Pearlman, Eric, Cobb, Brian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Antigen-Presenting Cells - immunology Gene Deletion Lymphocyte Activation Mice Mice, Inbred C57BL Myeloid Cells - immunology N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Original Polysaccharides - metabolism T-Lymphocytes - immunology Toll-Like Receptor 2 - metabolism
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