Human Alcohol Dehydrogenase: Structural Differences between the β and γ Subunits Suggest Parallel Duplications in Isoenzyme Evolution and Predominant Expression of Separate Gene Descendants in Livers of Different Mammals

Human alcohol dehydrogenase (ADH; alcohol:NAD+oxidoreductase, EC 1.1.1.1) occurs in multiple forms, which exhibit distinct electrophoretic mobilities and enzymatic properties. The homogeneous isoenzymes β1β1and γ1γ1were isolated from livers of Caucasians with ``typical'' ADH phenotype by d...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-10, Vol.81 (20), p.6320-6324
Hauptverfasser:	Buhler, Rolf, Hempel, John, Kaiser, Rudolf, Von Wartburg, Jean-Pierre, Vallee, Bert L., Jornvall, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Dehydrogenase Alcohol Oxidoreductases - genetics Alcohols Amino Acid Sequence Amino acids Animals Biochemistry Biological Evolution Chromatography Dehydrogenases Enzymes evolution Gene Expression Regulation Genetic loci Horses Horses - genetics Humans Isoenzymes - genetics Liver Liver - enzymology Macromolecular Substances man Peptide Fragments - isolation & purification Species Specificity subunit structure
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