Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands

Selective σ2 ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the σ2-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovere...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (24), p.6920-6922
Hauptverfasser:	Motel, William C., Healy, Jason R., Viard, Eddy, Pouw, Buddy, Martin, Kelly E., Matsumoto, Rae R., Coop, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	chemistry Cocaine dopamine Dopamine Plasma Membrane Transport Proteins - chemistry Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Ligands Methamphetamine Neurotransmitter Norepinephrine Plasma Membrane Transport Proteins - chemistry Norepinephrine Plasma Membrane Transport Proteins - metabolism piperazines Piperazines - chemistry Piperazines - metabolism Protein Binding Receptors, sigma - chemistry Receptors, sigma - metabolism Serotonin Plasma Membrane Transport Proteins - chemistry Serotonin Plasma Membrane Transport Proteins - metabolism Sigma receptor Structure-Activity Relationship Structure–activity relationships transporters
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