Mutational landscape of yeast mutator strains

The acquisition of mutations is relevant to every aspect of genetics, including cancer and evolution of species on Darwinian selection. Genome variations arise from rare stochastic imperfections of cellular metabolism and deficiencies in maintenance genes. Here, we established the genome-wide spectr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-02, Vol.111 (5), p.1897-1902
Hauptverfasser:	Serero, Alexandre, Jubin, Claire, Loeillet, Sophie, Legoix-Né, Patricia, Nicolas, Alain G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Biological Sciences Cell lines Chromosomes Chromosomes, Fungal - genetics DNA Evolution Gene Rearrangement - genetics Genes Genes, Fungal - genetics Genetic mutation Genomes Genomics Haploidy Mutation Mutation - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Sequence Analysis, DNA Yeasts
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