BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression

Dysfunctions of genome caretaker genes contribute to genomic instability and tumor initiation. Because many of the caretaker genes are also essential for cell viability, permanent loss of function of these genes would prohibit further tumor progression. How essential caretaker genes contribute to tu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-12, Vol.73 (23), p.7122-7133
Hauptverfasser:	HUANG, Yi-Yuan, LI DAI, GAINES, Dakim, DROZ-ROSARIO, Roberto, HUIMEI LU, JINGMEI LIU, ZHIYUAN SHEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Calcium-Binding Proteins - physiology Carcinogenesis - genetics Cell Cycle Proteins - physiology Cerebellar Neoplasms - genetics Cerebellar Neoplasms - pathology Disease Progression Genes, Tumor Suppressor - physiology Hedgehog Proteins - physiology Male Medical sciences Medulloblastoma - genetics Medulloblastoma - pathology Mice Mice, Inbred C57BL Mice, Transgenic Neoplasms - genetics Neoplasms - pathology Neurogenesis - genetics Nuclear Proteins - physiology Pharmacology. Drug treatments Signal Transduction - physiology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!