Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease

Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson's disease (PD). Paraquat interacts with cellular redox systems and causes mitochondrial dysfunction and the formation of reactive o...

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Veröffentlicht in:	BMC neuroscience 2014-01, Vol.15 (1), p.21-21, Article 21
Hauptverfasser:	Muthukumaran, Krithika, Leahy, Samantha, Harrison, Kate, Sikorska, Marianna, Sandhu, Jagdeep K, Cohen, Jerome, Keshan, Corrine, Lopatin, Daniel, Miller, Harvey, Borowy-Borowski, Henryk, Lanthier, Patricia, Weinstock, Shelly, Pandey, Siyaram
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Brain research Cell culture Cell death Cell Survival - drug effects Dopamine Drug dosages Feasibility Studies Free radicals Health aspects Health insurance Herbicides Heroin Hydroxylases Male Neurodegeneration Neurons Neurons - drug effects Neurons - pathology Neuroprotective Agents - administration & dosage Neuroprotective Agents - chemistry Neurosciences Paraquat Parkinson Disease - physiopathology Parkinson Disease - prevention & control Parkinson's disease Physiological aspects Rats Rats, Long-Evans Rifabutin - analogs & derivatives Software Solubility Studies Substantia Nigra - drug effects Substantia Nigra - pathology Substantia Nigra - physiopathology Treatment Outcome Tyrosine Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives Ubiquinone - chemistry Variance analysis Vitamin E Vitamins - administration & dosage Vitamins - chemistry Water - chemistry
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