Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine,...
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| Veröffentlicht in: | Journal of pharmacology & pharmacotherapeutics 2014-01, Vol.5 (1), p.33-38 |
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| creator | Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed |
| description | To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats.
Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration.
Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy. |
| doi_str_mv | 10.4103/0976-500X.124419 |
| format | Article |
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Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration.
Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.</description><identifier>ISSN: 0976-500X</identifier><identifier>EISSN: 0976-5018</identifier><identifier>DOI: 10.4103/0976-500X.124419</identifier><identifier>PMID: 24554908</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Antibiotics ; Dose-response relationship (Biochemistry) ; Kidneys ; Nephrology ; Pharmacology ; Pharmacology, Experimental ; Physiological aspects ; Research Paper ; Toxicity</subject><ispartof>Journal of pharmacology & pharmacotherapeutics, 2014-01, Vol.5 (1), p.33-38</ispartof><rights>COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jan-Mar 2014</rights><rights>Copyright: © Journal of Pharmacology and Pharmacotherapeutics 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-26f085f98a928490dc5c6b316304d680392609bd8435336fcd967a039c90c8fe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24554908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elsayed, Mossad Gamaleddin Ahmed</creatorcontrib><creatorcontrib>Elkomy, Ashraf Abdelhakim Ahmed</creatorcontrib><creatorcontrib>Gaballah, Mahmoud Salem</creatorcontrib><creatorcontrib>Elbadawy, Mohamed</creatorcontrib><title>Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats</title><title>Journal of pharmacology & pharmacotherapeutics</title><addtitle>J Pharmacol Pharmacother</addtitle><description>To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats.
Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration.
Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.</description><subject>Antibiotics</subject><subject>Dose-response relationship (Biochemistry)</subject><subject>Kidneys</subject><subject>Nephrology</subject><subject>Pharmacology</subject><subject>Pharmacology, Experimental</subject><subject>Physiological aspects</subject><subject>Research Paper</subject><subject>Toxicity</subject><issn>0976-500X</issn><issn>0976-5018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUU1vEzEQtRCIVqV3TmglJG4J489dc0AKFR-VqvYCUm-W47W7rnbtxXaA_nscJaSNhH3wzPi9N2M_hF5jWDIM9D3IViw4wO0SE8awfIZO9yXcPT_EcHuCznO-h7qoZMDkS3RCGOdMQneKPl3beUixxD_e-PLQRNcY6-zsJ_uhWTXB_q75POgx5jkmHxodil_7WLxpapZ0ya_QC6fHbM_35xn68eXz94tvi6ubr5cXq6uF4YSUBREOOu5kpyXpavPecCPWFAsKrBddHY4IkOu-Y5RTKpzppWh1LRsJpnOWnqGPO915s55sb2woSY9qTn7S6UFF7dXxTfCDuou_FJW4rW2qwNu9QIo_NzYXdR83KdSZFWaS8JYzkI-oOz1a5YOLVcxMPhu1opxLaAUjFbX8D6ru3k7exGCdr_UjwrsnhMHqsQw5jpviY8jHQNgBTYo5J-sOL8SgtsarrbNq66zaGV8pb57-zIHwz2b6FxCVpXs</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Elsayed, Mossad Gamaleddin Ahmed</creator><creator>Elkomy, Ashraf Abdelhakim Ahmed</creator><creator>Gaballah, Mahmoud Salem</creator><creator>Elbadawy, Mohamed</creator><general>Medknow Publications and Media Pvt. 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Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration.
Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>24554908</pmid><doi>10.4103/0976-500X.124419</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Antibiotics Dose-response relationship (Biochemistry) Kidneys Nephrology Pharmacology Pharmacology, Experimental Physiological aspects Research Paper Toxicity |
| title | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
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