Rapid interferometric imaging of printed drug laden multilayer structures
The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adher...
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| Veröffentlicht in: | Scientific reports 2014-02, Vol.4 (1), p.4020, Article 4020 |
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| creator | Sandler, Niklas Kassamakov, Ivan Ehlers, Henrik Genina, Natalja Ylitalo, Tuomo Haeggstrom, Edward |
| description | The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences. |
| doi_str_mv | 10.1038/srep04020 |
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In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep04020</identifier><identifier>PMID: 24503863</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>132/124 ; 639/624/1107/328/1650 ; 692/700/565/1436/152 ; Drug Delivery Systems ; Fabrication ; Humanities and Social Sciences ; Imaging, Three-Dimensional ; Interferometry - methods ; Microfluidic Analytical Techniques ; Microfluidics ; Microscopy, Interference ; multidisciplinary ; Nanostructures ; Pharmaceutical Preparations - chemical synthesis ; Polymers ; Polymers - chemistry ; Precision Medicine - methods ; Printing ; Quality assurance ; Scanning ; Science ; Surface Properties ; Topography</subject><ispartof>Scientific reports, 2014-02, Vol.4 (1), p.4020, Article 4020</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Feb 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. 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methods</topic><topic>Microfluidic Analytical Techniques</topic><topic>Microfluidics</topic><topic>Microscopy, Interference</topic><topic>multidisciplinary</topic><topic>Nanostructures</topic><topic>Pharmaceutical Preparations - chemical synthesis</topic><topic>Polymers</topic><topic>Polymers - chemistry</topic><topic>Precision Medicine - methods</topic><topic>Printing</topic><topic>Quality assurance</topic><topic>Scanning</topic><topic>Science</topic><topic>Surface Properties</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandler, Niklas</creatorcontrib><creatorcontrib>Kassamakov, Ivan</creatorcontrib><creatorcontrib>Ehlers, Henrik</creatorcontrib><creatorcontrib>Genina, Natalja</creatorcontrib><creatorcontrib>Ylitalo, Tuomo</creatorcontrib><creatorcontrib>Haeggstrom, Edward</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandler, Niklas</au><au>Kassamakov, Ivan</au><au>Ehlers, Henrik</au><au>Genina, Natalja</au><au>Ylitalo, Tuomo</au><au>Haeggstrom, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid interferometric imaging of printed drug laden multilayer structures</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-02-07</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>4020</spage><pages>4020-</pages><artnum>4020</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. 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| subjects | 132/124 639/624/1107/328/1650 692/700/565/1436/152 Drug Delivery Systems Fabrication Humanities and Social Sciences Imaging, Three-Dimensional Interferometry - methods Microfluidic Analytical Techniques Microfluidics Microscopy, Interference multidisciplinary Nanostructures Pharmaceutical Preparations - chemical synthesis Polymers Polymers - chemistry Precision Medicine - methods Printing Quality assurance Scanning Science Surface Properties Topography |
| title | Rapid interferometric imaging of printed drug laden multilayer structures |
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