N-Acetylglucosaminylation of Serine-Aspartate Repeat Proteins Promotes Staphylococcus aureus Bloodstream Infection

Staphylococcus aureus secretes products that convert host fibrinogen to fibrin and promote its agglutination with fibrin fibrils, thereby shielding bacteria from immune defenses. The agglutination reaction involves ClfA (clumping factor A), a surface protein with serine-aspartate (SD) repeats that c...

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Veröffentlicht in:	The Journal of biological chemistry 2014-02, Vol.289 (6), p.3478-3486
Hauptverfasser:	Thomer, Lena, Becker, Samuel, Emolo, Carla, Quach, Austin, Kim, Hwan Keun, Rauch, Sabine, Anderson, Mark, LeBlanc, James F., Schneewind, Olaf, Faull, Kym F., Missiakas, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - genetics Acetylglucosamine - immunology Acetylglucosamine - metabolism Agglutination Animals ClfA Coagulase - genetics Coagulase - immunology Coagulase - metabolism Coagulation Factors Fibrin Fibrin - genetics Fibrin - immunology Fibrin - metabolism Glucosyltransferases - genetics Glucosyltransferases - immunology Glucosyltransferases - metabolism Glycosylation Glycosyltransferases Humans Infectious Diseases Mice Microbiology Serine-Aspartate Repeat Staphylococcal Infections - genetics Staphylococcal Infections - immunology Staphylococcal Infections - metabolism Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - immunology Staphylococcus aureus - metabolism
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