T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes

The 20S proteasome is almost exclusively localized within cells. High levels of extracellular proteasomes are also found circulating in the blood plasma of patients suffering from a variety of inflammatory, autoimmune and neoplastic diseases. However, the origin of these proteasomes remained enigmat...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2014-01, Vol.18 (1), p.59-68
Hauptverfasser:	Bochmann, Isabel, Ebstein, Frédéric, Lehmann, Andrea, Wohlschlaeger, Jeremias, Sixt, Stephan Urs, Kloetzel, Peter‐Michael, Dahlmann, Burkhardt
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Blood circulation Blood plasma Calcimycin Calcium Calcium chloride Calcium ionophores Cell culture Cell cycle Cell-Derived Microparticles - enzymology Cells, Cultured circulating Enzymes Experiments extracellular Fluids Humans Immunoglobulins Incubation Lymphocytes Lymphocytes T Membrane vesicles Membranes Microparticles Original Ovarian cancer Penicillin proteasome Proteasome activator Proteasome activator PA28a/b Proteasome Endopeptidase Complex - metabolism Proteasome Endopeptidase Complex - secretion Proteasomes Protein Subunits - metabolism Protein Subunits - secretion Proteomes Sphingomyelin phosphodiesterase Sphingomyelin Phosphodiesterase - chemistry sphingomyelinase T lymphocytes T-Lymphocytes - enzymology T-Lymphocytes - secretion Vesicles
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