Malignant bowel obstruction: A retrospective clinical analysis
Malignant bowel obstruction (MBO) is a disease with a poor prognosis, particularly in patients with advanced bowel or gynecological cancers. Multimodality teatments may be used to relieve the symptoms in patients with MBO; however, there is currently no consensus regarding the optimal treatment and...
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| Veröffentlicht in: | Molecular and clinical oncology 2014-01, Vol.2 (1), p.13-18 |
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| creator | CHEN, JIA-HONG HUANG, TZU-CHUAN CHANG, PING-YING DAI, MING-SHEN HO, CHING-LIANG CHEN, YEU-CHIN CHAO, TSU-YI KAO, WOEI-YAU |
| description | Malignant bowel obstruction (MBO) is a disease with a poor prognosis, particularly in patients with advanced bowel or gynecological cancers. Multimodality teatments may be used to relieve the symptoms in patients with MBO; however, there is currently no consensus regarding the optimal treatment and no strong evidence supporting the efficacy of any treatment in improving the quality of life (QOL) and prolonging survival. We conducted a search through our medical center database of cancer registries for MBO cases between January, 1995 and December, 2008 and analyzed the clinicopathological characteristics and association between treatments and prognosis or QOL. The primary type of cancer causing MBO was found to be adenocarcinoma of colon. The overall survival time was found to be significantly higher among patients presenting with MBO as the initial symptom and improved QOL was achieved in patients who received surgical treatment. The mean survival time and the functional status of colorectal cancer patients receiving targeted therapy and chemotherapy were more satisfactory compared with those receiving surgery alone or conservative treatment. Furthermore, for end-stage cancer patients with MBO, hospice care was effective in reducing pain scores and relieving the symptoms of the disease. |
| doi_str_mv | 10.3892/mco.2013.216 |
| format | Article |
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Multimodality teatments may be used to relieve the symptoms in patients with MBO; however, there is currently no consensus regarding the optimal treatment and no strong evidence supporting the efficacy of any treatment in improving the quality of life (QOL) and prolonging survival. We conducted a search through our medical center database of cancer registries for MBO cases between January, 1995 and December, 2008 and analyzed the clinicopathological characteristics and association between treatments and prognosis or QOL. The primary type of cancer causing MBO was found to be adenocarcinoma of colon. The overall survival time was found to be significantly higher among patients presenting with MBO as the initial symptom and improved QOL was achieved in patients who received surgical treatment. The mean survival time and the functional status of colorectal cancer patients receiving targeted therapy and chemotherapy were more satisfactory compared with those receiving surgery alone or conservative treatment. Furthermore, for end-stage cancer patients with MBO, hospice care was effective in reducing pain scores and relieving the symptoms of the disease.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2013.216</identifier><identifier>PMID: 24649301</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Abdomen ; bowel obstruction ; cancer ; Cancer therapies ; Chemotherapy ; Clinical trials ; Colorectal cancer ; Constipation ; Hospice care ; Intestinal obstruction ; Intestines ; Management ; Medical prognosis ; Medical research ; Medicine, Experimental ; Obstructions ; Oncology ; Ovarian cancer ; Pain ; Palliative care ; Parenteral nutrition ; Patients ; Radiation therapy ; Studies ; Surgery</subject><ispartof>Molecular and clinical oncology, 2014-01, Vol.2 (1), p.13-18</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><rights>Copyright © 2013, Spandidos Publications 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-af726979f99f28ca3bddb99d56962ead0a53a82ce360d69e339a33f0d15ccb1b3</citedby><cites>FETCH-LOGICAL-c441t-af726979f99f28ca3bddb99d56962ead0a53a82ce360d69e339a33f0d15ccb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915666/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915666/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,5556,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24649301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, JIA-HONG</creatorcontrib><creatorcontrib>HUANG, TZU-CHUAN</creatorcontrib><creatorcontrib>CHANG, PING-YING</creatorcontrib><creatorcontrib>DAI, MING-SHEN</creatorcontrib><creatorcontrib>HO, CHING-LIANG</creatorcontrib><creatorcontrib>CHEN, YEU-CHIN</creatorcontrib><creatorcontrib>CHAO, TSU-YI</creatorcontrib><creatorcontrib>KAO, WOEI-YAU</creatorcontrib><title>Malignant bowel obstruction: A retrospective clinical analysis</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>Malignant bowel obstruction (MBO) is a disease with a poor prognosis, particularly in patients with advanced bowel or gynecological cancers. Multimodality teatments may be used to relieve the symptoms in patients with MBO; however, there is currently no consensus regarding the optimal treatment and no strong evidence supporting the efficacy of any treatment in improving the quality of life (QOL) and prolonging survival. We conducted a search through our medical center database of cancer registries for MBO cases between January, 1995 and December, 2008 and analyzed the clinicopathological characteristics and association between treatments and prognosis or QOL. The primary type of cancer causing MBO was found to be adenocarcinoma of colon. The overall survival time was found to be significantly higher among patients presenting with MBO as the initial symptom and improved QOL was achieved in patients who received surgical treatment. The mean survival time and the functional status of colorectal cancer patients receiving targeted therapy and chemotherapy were more satisfactory compared with those receiving surgery alone or conservative treatment. Furthermore, for end-stage cancer patients with MBO, hospice care was effective in reducing pain scores and relieving the symptoms of the disease.</description><subject>Abdomen</subject><subject>bowel obstruction</subject><subject>cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Colorectal cancer</subject><subject>Constipation</subject><subject>Hospice care</subject><subject>Intestinal obstruction</subject><subject>Intestines</subject><subject>Management</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Obstructions</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Pain</subject><subject>Palliative care</subject><subject>Parenteral nutrition</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Studies</subject><subject>Surgery</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkU1v1DAQhiMEolXpjTOKxAEOZPFH4s1wqLSq-JKKuMDZmtjO4sqxFztp1X_PrLYsFOE52Jp55rVm3qp6ztlK9iDeTiatBONyJbh6VJ0K1kIDrYLHx3fHTqrzUq4ZHVgz0cHT6kS0qgXJ-Gl18QWD30aMcz2kWxfqNJQ5L2b2Kb6rN3V2c05l5yhx42oTfPQGQ40Rw13x5Vn1ZMRQ3Pn9fVZ9__D-2-Wn5urrx8-Xm6vGtC2fGxzXQsEaRoBR9AblYO0AYDsFSji0DDuJvTBOKmYVOCkBpRyZ5Z0xAx_kWXVx0N0tw-SscXHOGPQu-wnznU7o9cNK9D_0Nt1oCbxTSpHA63uBnH4ursx68sW4EDC6tBTNe6G6Hvq1IPTlP-h1WjINTBRI0XaSgfxDbTE47eOY6F-zF9WblgvOyQZO1Oo_FIV1kzcputFT_kHDm0ODobWX7MbjjJzpveWaLNd7yzVZTviLv_dyhH8bTMCrA1B2GK23qRwZEmqYaBhvGIHyF46Usu8</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>CHEN, JIA-HONG</creator><creator>HUANG, TZU-CHUAN</creator><creator>CHANG, PING-YING</creator><creator>DAI, MING-SHEN</creator><creator>HO, CHING-LIANG</creator><creator>CHEN, YEU-CHIN</creator><creator>CHAO, TSU-YI</creator><creator>KAO, WOEI-YAU</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Malignant bowel obstruction: A retrospective clinical analysis</title><author>CHEN, JIA-HONG ; HUANG, TZU-CHUAN ; CHANG, PING-YING ; DAI, MING-SHEN ; HO, CHING-LIANG ; CHEN, YEU-CHIN ; CHAO, TSU-YI ; KAO, WOEI-YAU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-af726979f99f28ca3bddb99d56962ead0a53a82ce360d69e339a33f0d15ccb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdomen</topic><topic>bowel obstruction</topic><topic>cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Colorectal cancer</topic><topic>Constipation</topic><topic>Hospice care</topic><topic>Intestinal obstruction</topic><topic>Intestines</topic><topic>Management</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Obstructions</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Pain</topic><topic>Palliative care</topic><topic>Parenteral nutrition</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, JIA-HONG</creatorcontrib><creatorcontrib>HUANG, TZU-CHUAN</creatorcontrib><creatorcontrib>CHANG, PING-YING</creatorcontrib><creatorcontrib>DAI, MING-SHEN</creatorcontrib><creatorcontrib>HO, CHING-LIANG</creatorcontrib><creatorcontrib>CHEN, YEU-CHIN</creatorcontrib><creatorcontrib>CHAO, TSU-YI</creatorcontrib><creatorcontrib>KAO, WOEI-YAU</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, JIA-HONG</au><au>HUANG, TZU-CHUAN</au><au>CHANG, PING-YING</au><au>DAI, MING-SHEN</au><au>HO, CHING-LIANG</au><au>CHEN, YEU-CHIN</au><au>CHAO, TSU-YI</au><au>KAO, WOEI-YAU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant bowel obstruction: A retrospective clinical analysis</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2</volume><issue>1</issue><spage>13</spage><epage>18</epage><pages>13-18</pages><issn>2049-9450</issn><eissn>2049-9469</eissn><abstract>Malignant bowel obstruction (MBO) is a disease with a poor prognosis, particularly in patients with advanced bowel or gynecological cancers. Multimodality teatments may be used to relieve the symptoms in patients with MBO; however, there is currently no consensus regarding the optimal treatment and no strong evidence supporting the efficacy of any treatment in improving the quality of life (QOL) and prolonging survival. We conducted a search through our medical center database of cancer registries for MBO cases between January, 1995 and December, 2008 and analyzed the clinicopathological characteristics and association between treatments and prognosis or QOL. The primary type of cancer causing MBO was found to be adenocarcinoma of colon. The overall survival time was found to be significantly higher among patients presenting with MBO as the initial symptom and improved QOL was achieved in patients who received surgical treatment. The mean survival time and the functional status of colorectal cancer patients receiving targeted therapy and chemotherapy were more satisfactory compared with those receiving surgery alone or conservative treatment. Furthermore, for end-stage cancer patients with MBO, hospice care was effective in reducing pain scores and relieving the symptoms of the disease.</abstract><cop>England</cop><pub>D.A. Spandidos</pub><pmid>24649301</pmid><doi>10.3892/mco.2013.216</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2049-9450 |
| ispartof | Molecular and clinical oncology, 2014-01, Vol.2 (1), p.13-18 |
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| language | eng |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Abdomen bowel obstruction cancer Cancer therapies Chemotherapy Clinical trials Colorectal cancer Constipation Hospice care Intestinal obstruction Intestines Management Medical prognosis Medical research Medicine, Experimental Obstructions Oncology Ovarian cancer Pain Palliative care Parenteral nutrition Patients Radiation therapy Studies Surgery |
| title | Malignant bowel obstruction: A retrospective clinical analysis |
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