Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin

Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention. Fly models of complex disease would enable high-resolution mapping of disease-modifying loci and the identification of novel targets for therap...

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Veröffentlicht in:	Genetics (Austin) 2014-02, Vol.196 (2), p.539-555
Hauptverfasser:	Park, Soo-Young, Ludwig, Michael Z, Tamarina, Natalia A, He, Bin Z, Carl, Sarah H, Dickerson, Desiree A, Barse, Levi, Arun, Bharath, Williams, Calvin L, Miles, Cecelia M, Philipson, Louis H, Steiner, Donald F, Bell, Graeme I, Kreitman, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Cluster Analysis Diabetes Diabetes Mellitus - genetics Disease Models, Animal Drosophila melanogaster Eye - metabolism Female Gene Dosage Gene Expression Profiling Genetic research Genotype & phenotype Humans Insects Investigations Male Mutation Phenotype Proinsulin - chemistry Proinsulin - genetics Protein Folding Quantitative Trait, Heritable Transcriptome Transgenes Wings, Animal - metabolism
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