Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats
Background and Objective. Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-9 |
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| creator | Longauer, František Radoňak, Jozef Kilík, Róbert Vidová, Martina Vasilenko, Tomáš Lacjaková, Kamila Lakyová, Lucia Sabo, Ján Kruzliak, Peter |
| description | Background and Objective. Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres. |
| doi_str_mv | 10.1155/2014/269253 |
| format | Article |
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Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/269253</identifier><identifier>PMID: 24551842</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Biomedical research ; Clinical medicine ; Collagen ; Diabetes ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - therapy ; Drug dosages ; Experiments ; Extracellular matrix ; Hospitals ; Humans ; Hyperglycemia ; Immune System Diseases ; Inflammation - pathology ; Inflammation - therapy ; Lasers ; Lasers in surgery ; Leukocyte Disorders ; Light emitting diodes ; Low-Level Light Therapy ; Male ; Medical research ; Phototherapy ; Radiation Dosage ; Rats ; Rodents ; Skin - injuries ; Skin - radiation effects ; Studies ; Surgery ; Wound healing ; Wound Healing - radiation effects</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Róbert Kilík et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Róbert Kilík et al. Róbert Kilík et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Róbert Kilík et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-7e8da1d58008dbf3f8a7254594bffe6a54e8ca207301e9a0896974d13775afab3</citedby><cites>FETCH-LOGICAL-c527t-7e8da1d58008dbf3f8a7254594bffe6a54e8ca207301e9a0896974d13775afab3</cites><orcidid>0000-0002-7069-3784</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914322/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914322/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24551842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Oliveira, Marília Gerhardt</contributor><creatorcontrib>Longauer, František</creatorcontrib><creatorcontrib>Radoňak, Jozef</creatorcontrib><creatorcontrib>Kilík, Róbert</creatorcontrib><creatorcontrib>Vidová, Martina</creatorcontrib><creatorcontrib>Vasilenko, Tomáš</creatorcontrib><creatorcontrib>Lacjaková, Kamila</creatorcontrib><creatorcontrib>Lakyová, Lucia</creatorcontrib><creatorcontrib>Sabo, Ján</creatorcontrib><creatorcontrib>Kruzliak, Peter</creatorcontrib><title>Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background and Objective. Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.</description><subject>Animals</subject><subject>Biomedical research</subject><subject>Clinical medicine</subject><subject>Collagen</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Drug dosages</subject><subject>Experiments</subject><subject>Extracellular matrix</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Immune System Diseases</subject><subject>Inflammation - pathology</subject><subject>Inflammation - therapy</subject><subject>Lasers</subject><subject>Lasers in surgery</subject><subject>Leukocyte Disorders</subject><subject>Light emitting diodes</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medical research</subject><subject>Phototherapy</subject><subject>Radiation Dosage</subject><subject>Rats</subject><subject>Rodents</subject><subject>Skin - injuries</subject><subject>Skin - radiation effects</subject><subject>Studies</subject><subject>Surgery</subject><subject>Wound healing</subject><subject>Wound Healing - radiation effects</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0ktv00AQB3ALgWhVeuIMWokLogr1vvy4VIqaQJEiiqCI42psj5Mtzm66azfKjWs_Bd-NT8JEKeFxwRdbsz__d0aaJHnK09eca30qUq5ORVYKLR8kh0JyNcq44g_331IeJMcxXqf0FDxLy-xxciCU1rxQ4jD5Pm1brHvmWza9GaBjE7Ddhk18xMjG9cLiLTasooolGND17INfY2ATdNH2lhT9OvPr0Yxkx2YQ6fBqgQFWGwY9y6T-8e3OLZl37HKFjn36ah374gfXsAuEzro5o8J7H5Z0O1B1YqHC3tbsI_TxSfKohS7i8f37KPn8Znp1fjGaXb59dz6ejWot8n6UY9EAb3RBQzZVK9sCcqGVLlVFbWegFRY1iDSXKccS0qLMylw1XOa5hhYqeZSc7XJXQ7XEpqZBA3RmFewSwsZ4sObvE2cXZu5vjSy5kkJQwMv7gOBvBoy9WdpYY9eBQz9Ew7VUBTleEH3xD732Q3A0Hqls21KpxG81hw6Nda2ne-ttqBkrkaeUlaekTnaqDj7GgO2-ZZ6a7YaY7YaY3YaQfv7nlHv7ax8IvNqBhXUNrO1_0p7tMBLBFvZY6aIsM_kTbK3Lkg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Longauer, František</creator><creator>Radoňak, Jozef</creator><creator>Kilík, Róbert</creator><creator>Vidová, Martina</creator><creator>Vasilenko, Tomáš</creator><creator>Lacjaková, Kamila</creator><creator>Lakyová, Lucia</creator><creator>Sabo, Ján</creator><creator>Kruzliak, Peter</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7069-3784</orcidid></search><sort><creationdate>20140101</creationdate><title>Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats</title><author>Longauer, František ; Radoňak, Jozef ; Kilík, Róbert ; Vidová, Martina ; Vasilenko, Tomáš ; Lacjaková, Kamila ; Lakyová, Lucia ; Sabo, Ján ; Kruzliak, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-7e8da1d58008dbf3f8a7254594bffe6a54e8ca207301e9a0896974d13775afab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomedical research</topic><topic>Clinical medicine</topic><topic>Collagen</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Drug dosages</topic><topic>Experiments</topic><topic>Extracellular matrix</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Immune System Diseases</topic><topic>Inflammation - pathology</topic><topic>Inflammation - therapy</topic><topic>Lasers</topic><topic>Lasers in surgery</topic><topic>Leukocyte Disorders</topic><topic>Light emitting diodes</topic><topic>Low-Level Light Therapy</topic><topic>Male</topic><topic>Medical research</topic><topic>Phototherapy</topic><topic>Radiation Dosage</topic><topic>Rats</topic><topic>Rodents</topic><topic>Skin - injuries</topic><topic>Skin - radiation effects</topic><topic>Studies</topic><topic>Surgery</topic><topic>Wound healing</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Longauer, František</creatorcontrib><creatorcontrib>Radoňak, Jozef</creatorcontrib><creatorcontrib>Kilík, Róbert</creatorcontrib><creatorcontrib>Vidová, Martina</creatorcontrib><creatorcontrib>Vasilenko, Tomáš</creatorcontrib><creatorcontrib>Lacjaková, Kamila</creatorcontrib><creatorcontrib>Lakyová, Lucia</creatorcontrib><creatorcontrib>Sabo, Ján</creatorcontrib><creatorcontrib>Kruzliak, Peter</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24551842</pmid><doi>10.1155/2014/269253</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7069-3784</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomedical research Clinical medicine Collagen Diabetes Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - therapy Drug dosages Experiments Extracellular matrix Hospitals Humans Hyperglycemia Immune System Diseases Inflammation - pathology Inflammation - therapy Lasers Lasers in surgery Leukocyte Disorders Light emitting diodes Low-Level Light Therapy Male Medical research Phototherapy Radiation Dosage Rats Rodents Skin - injuries Skin - radiation effects Studies Surgery Wound healing Wound Healing - radiation effects |
| title | Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats |
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