Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat f...
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Veröffentlicht in: | The Journal of neuroscience 2014-02, Vol.34 (6), p.2231-2243 |
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creator | Shigemoto-Mogami, Yukari Hoshikawa, Kazue Goldman, James E Sekino, Yuko Sato, Kaoru |
description | Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1β, IL-6, TNF-α, and IFN-γ) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ. In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines. |
doi_str_mv | 10.1523/JNEUROSCI.1619-13.2014 |
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In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1β, IL-6, TNF-α, and IFN-γ) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ. In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Cerebral Ventricles - cytology</subject><subject>Cerebral Ventricles - physiology</subject><subject>Female</subject><subject>Male</subject><subject>Microglia - physiology</subject><subject>Neurogenesis - physiology</subject><subject>Oligodendroglia - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhL1Q-csnisR07viChVYGilkqFno3jzO4aee0lTiqVX0-itkt76mmkN2-eZuYj5ATYEmouPnz7fnp9dfljdbYEBaYCseQM5AuymLqm4pLBS7JgXLNKSS2PyJtSfjPGNAP9mhxxWTMQii_Ir4vg-7yJwVFMW5c80oTjpGDCEgp1qaM5hk3uMHX_5ZDosEWKro-3dJ_LkNzgIi1je4Np6IMfo-vp35zwLXm1drHgu_t6TK4_n_5cfa3OL7-crT6dV75Waqi0QvReS2ZaI5tu3WLLmqZpa1YDR3Se-6l6pbSGRivhdSNbyVuzBmmUQXFMPt7l7sd2h52f13DR7vuwc_2tzS7Yp50UtnaTb6wwIBrNpoD39wF9_jNiGewuFI8xuoR5LBYarg2H6bPPW6UxAIqr2arurNOXS-lxfdgImJ1J2gNJO5O0IOxMcho8eXzPYewBnfgHD12dow</recordid><startdate>20140205</startdate><enddate>20140205</enddate><creator>Shigemoto-Mogami, Yukari</creator><creator>Hoshikawa, Kazue</creator><creator>Goldman, James E</creator><creator>Sekino, Yuko</creator><creator>Sato, Kaoru</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20140205</creationdate><title>Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone</title><author>Shigemoto-Mogami, Yukari ; Hoshikawa, Kazue ; Goldman, James E ; Sekino, Yuko ; Sato, Kaoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-76eecc7409b948dfbeb0888b50512eeac2c12ec667718763c784b42b9f14969e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Cerebral Ventricles - cytology</topic><topic>Cerebral Ventricles - physiology</topic><topic>Female</topic><topic>Male</topic><topic>Microglia - physiology</topic><topic>Neurogenesis - physiology</topic><topic>Oligodendroglia - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shigemoto-Mogami, Yukari</creatorcontrib><creatorcontrib>Hoshikawa, Kazue</creatorcontrib><creatorcontrib>Goldman, James E</creatorcontrib><creatorcontrib>Sekino, Yuko</creatorcontrib><creatorcontrib>Sato, Kaoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shigemoto-Mogami, Yukari</au><au>Hoshikawa, Kazue</au><au>Goldman, James E</au><au>Sekino, Yuko</au><au>Sato, Kaoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2014-02-05</date><risdate>2014</risdate><volume>34</volume><issue>6</issue><spage>2231</spage><epage>2243</epage><pages>2231-2243</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. 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subjects | Animals Animals, Newborn Cell Proliferation Cells, Cultured Cerebral Ventricles - cytology Cerebral Ventricles - physiology Female Male Microglia - physiology Neurogenesis - physiology Oligodendroglia - physiology Rats Rats, Wistar |
title | Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone |
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