Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone

Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat f...

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Veröffentlicht in:The Journal of neuroscience 2014-02, Vol.34 (6), p.2231-2243
Hauptverfasser: Shigemoto-Mogami, Yukari, Hoshikawa, Kazue, Goldman, James E, Sekino, Yuko, Sato, Kaoru
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container_end_page 2243
container_issue 6
container_start_page 2231
container_title The Journal of neuroscience
container_volume 34
creator Shigemoto-Mogami, Yukari
Hoshikawa, Kazue
Goldman, James E
Sekino, Yuko
Sato, Kaoru
description Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1β, IL-6, TNF-α, and IFN-γ) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ. In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.
doi_str_mv 10.1523/JNEUROSCI.1619-13.2014
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subjects Animals
Animals, Newborn
Cell Proliferation
Cells, Cultured
Cerebral Ventricles - cytology
Cerebral Ventricles - physiology
Female
Male
Microglia - physiology
Neurogenesis - physiology
Oligodendroglia - physiology
Rats
Rats, Wistar
title Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
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