The Glycosyltransferase Involved in Thurandacin Biosynthesis Catalyzes Both O- and S‑Glycosylation

The S-glycosyltransferase SunS is a recently discovered enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of proteins. This study reports the discovery of a second S-glycosyltransferase, ThuS, and shows that ThuS catalyzes both S-glycosylation of the thiol of c...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-01, Vol.136 (1), p.84-87
Hauptverfasser:	Wang, Huan, Oman, Trent J, Zhang, Ran, Garcia De Gonzalo, Chantal V, Zhang, Qi, van der Donk, Wilfred A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus thuringiensis - enzymology Bacillus thuringiensis - genetics Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Catalysis Glycopeptides - biosynthesis Glycopeptides - genetics Glycosylation Glycosyltransferases - metabolism Oxygen - metabolism Peptides - chemistry Peptides - genetics Sulfur - metabolism
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